联合应用潘托拉唑和复方铝酸铋预防急性冠脉综合征后上消化道出血

Clinical Observation on Prevention of Upper Gastrointestinal Bleeding by Pantoprazole and Compound Bismuth Aluminate

关键词:  急性冠脉综合征  上消化道出血  质子泵抑制剂  黏膜保护剂

Key words:  acute coronary syndrome  upper gastrointestinal bleeding  proton pump inhibitor  compound bismuth aluminate

摘要:

目的 评价联合应用潘托拉唑与复方铝酸铋预防急性冠脉综合征后上消化道出血的疗效。方法 将2006—2008年住院的急性冠脉综合征患者167例纳入本组研究，其中男147例、女20例，年龄47-85岁，平均(73±12)岁，随机分为联合治疗组(n=51)、潘托拉唑组(n=61)和复方铝酸铋组(n=55)。急性冠脉综合征常规治疗的方法相同。观察3组并发上消化道出血的发生率。结果 3组急性冠脉综合征后上消化道出血的发生率分别为：潘托拉唑组13.11%、复方铝酸铋组20.0%、联合治疗组3.92%。联合治疗组上消化道出血的发生率明显降低(P<0.05)。结论 急性冠脉综合征后联合应用胃黏膜保护剂与质子泵抑制剂可以更加有效预防上消化道出血。

Abstract:

OBJECTIVE To study the prevention of upper gastrointestinal bleeding after acute coronary syndrome by pantoprazole and compound bismuth aluminate(CBA). METHODS A total of 167 in-patients with acute coronary syndrome from the year of 2006-2008 were enrolled in the study. The patients were divided into pantoprazole group(n=61), CBA group(n=55) and combined group(n=51). Besides，all the patients were treated with routine therapy. The morbidity of upper gastrointestinal bleeding after acute coronary syndrome was observed and recorded. RESULTS The morbidity of upper gastrointestinal bleeding after acute coronary syndrome was 13.11% in the pantoprazole group, 20.0% in the CBA group and 3.92% in the combined group, respectively. The difference among the three groups was significant(P<0.05). CONCLUSION Combination the proton pump inhibitor and CBA could prevent upper gastrointestinal bleeding after acute coronary syndrome.