布林佐胺联合噻吗心安治疗开角型青光眼的临床研究

Clinical Observation of Brinzolamide Combined Timolol for Treating the Patients with Open-Angle Glaucoma

关键词:  布林佐胺  噻吗心安  降眼压  开角型青光眼

Key words:  Brinzolamide  Timolol  anti-glaucoma  open-angle glaucoma

摘要:

目的 观察布林佐胺联合噻吗心安治疗开角型青光眼的临床疗效和安全性。方法 将30例(52只眼)开角型青光眼患者随机分为治疗组和对照组。治疗组采用 1%布林佐胺联合0.25%噻吗心安滴眼液治疗，对照组采用0.25%噻吗心安滴眼液治疗，比较2种治疗方法的降眼压作用及不良反应。结果 2组治疗后2，6，12周眼压均有所下降，与治疗前比较有统计学意义(P<0.05)，且治疗组与对照组比较有统计学意义(P<0.05)；治疗后治疗组无血压变化和心率抑制，对照组无血压变化，但出现心率抑制现象。2组均未见明显不良反应。结论 布林佐胺联合噻吗心安治疗开角型青光眼具有明显的降眼压作用，且无明显不良反应，值得临床推广应用。

Abstract:

OBJECTIVE To investigate the clinical efficacy and safety of Brinzolamide combined Timolol for treating the patients with open-angle glaucoma. METHODS 52 eyes of 30 cases of patients with open-angle glaucoma were randomly divided into treatment group and control group. The treatment group was given treatment of 1% Brinzolamide combined 0.25% Timolol eye drops. The control group was given treatment of 0.25% Timolol eye drops, Comparison the two eye drops to lower intraocular pressure and side effects. RESULTS After 2, 6, 12 weeks of treatment, the intraocular pressure of the two groups decreased, compared with the pre- treatment the difference was significant (P<0.05). Compared with the control group and the treatment group there was significant difference (P<0.05). After treatment, there wasn’t inhibition of blood pressure and heart rate in the treatment group.The control group had no blood pressure changes, but there were inhibition of heart rate. There were no significant adverse reactions and systemic side effects of the two groups. CONCLUSION Brinzolamide combined Timolol for treating the patients with open-angle glaucoma has significant anti-glaucoma effect, and no adverse reaction. It is worthy of clinical application.