多肽修饰脂质体靶向药物递送系统研究进展

Advances in Peptide-Modified Liposome Targeted Drug Delivery System

关键词:  多肽  脂质体  靶向药物递送系统  配体  受体

Key words:  peptide  liposome  targeted drug delivery system  ligand  receptor

摘要:

目的 介绍近年来多肽修饰脂质体靶向药物递送系统的研究进展。方法 查阅和归纳总结近几年相关文献。结果 阐述了精氨酸-甘氨酸-天冬氨酸(RGD)多肽、丙氨酸-脯氨酸-精氨酸-脯氨酸-甘氨酸(APRPG)多肽、细胞穿透肽(CPP)、血管活性肠肽(VIP)等修饰脂质体的研究进展。多肽修饰的包载药物的脂质体可以增加药物在体内的选择性，减少药物毒副作用，提高药物治疗指数。结论 多肽分子是机体内一类重要的生物活性物质，将其作为导向物以配体-受体特异性结合的方式应用于靶向药物递送系统，具有良好的研究价值和应用前景。

Abstract:

OBJECTIVE To introduce the advances of peptide-modified liposome targeted drug delivery system. METHODS The relevant literatures in recent years were referred and summarized. RESULTS The advances of liposomes modified by arginine-glycine-aspartic (RGD) peptide, alanine-proline-arginine-proline-glycine (APRPG) peptide, cell-penetrating peptide (CPP), vasoactive intestinal peptide (VIP) were elaborated. Peptide-modified drug-loaded liposomes may increase the selectivity of drugs in vivo and reduce side effects of drugs to improve their therapeutic index. CONCLUSION Peptide molecules are a class of important bioactive substances to the body, which are applied in targeted drug delivery system by specific-combination of ligand-receptor with good values and application prospects.