纳他霉素等多烯类抗生素作用机制及研究方法

The Mechanism of Action and Research Methods of Natamycin and Polyene Antimycotics

关键词:  抗真菌药物  多烯类抗生素  两性霉素B  纳他霉素  作用机制

Key words:  antifungal  polyene antibiotics  antifungal B  natamycin  mechanism of action

摘要:

目的 介绍纳他霉素的作用机制及近年来的研究方法。方法 综合国内外文献报道，简述纳他霉素等多烯类抗生素的性质、作用机制及研究方法。结果 研究抗真菌药物的作用机制有利于研发新型药物和改善己有药物的药学特性，并且能够指导临床合理的联合用药，新技术新方法的应用将有助于深入研究多烯类抗真菌抗生素的作用机制。结论 本文为研究纳他霉素作用机制及国内拥有自主知识产权的产品开发提供参考。

Abstract:

OBJECTIVE To introduce the mechanism of action and research methods in recent years of natamycin. METHODS Sketch the nature, mechanism of action and research method of natamycin and other polyene antibiotics according to relative literatures. RESULTS To study the mechanism action of antifungal drugs is not only in favor of the study of new type drug and the improvement of the pharmacy character of the existing drugs, but also can guide the clinical reasonable drug combination. The application of the new technology and new method can help study the mechanism action of the polyene antifungal drugs deeply. CONCLUSION This paper gives consulation to the further research of natamycin and exploitation of new pruduct which has independent intellectual property right.