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| 摘要: |
| 目的 研究氧化钌在顺式凯林内酯合成上的应用。方法 以2-甲基-3-丁炔-2-醇和7-羟基香豆素为原料，经过羟基的烃化以及Claisen重排反应得到邪蒿素，再以邪蒿素为原料，利用氧化钌为催化氧化剂，得到顺式凯林内酯。结果 产物经熔点测定、质谱及核磁共振氢谱得到确认。结论 该研究给顺式凯林内酯的合成提供了一种新的方法。 |
| 关键词: 邪蒿素 凯林内酯 氧化钌 合成 |
| DOI： |
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| Improvement of the Synthesis of (±)-cis-Khellactone |
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YOU Wenchun JIN Hui HAN Daxiong*
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| Abstract: |
| OBJECTIVE To research oxidative ruthenium used in the application of the synthesis of (±)-cis-khellactone. METHODS First seselin was synthesized from 2-methyl-3-butyn-2-ol and 7-hydroxycoumarin by alkylation of hydroxy group and Claisen rearrangement. And then oxidative ruthenium was used to catalyze and oxidize seselin. Successfully, (±)-cis- khellactone was produced. RESULTS The structure was characterized by MS and NMR. CONCLUSION This study provides a new method to synthesize (±)-cis-khellactone. |
| Key words: seselin khellactone oxidative ruthenium synthesis |
