| 引用本文: | 顾宇虹,宁海宁,王金华,肖斌,杜冠华.他汀类药物致新发糖尿病的危险因素、病理机制及防治措施研究进展[J].中国现代应用药学,2021,38(2):244-251. |
| GU Yuhong,NING Haining,WANG Jinhua,XIAO Bin,DU Guanhua.Research Progress on the Risk Factors, Pathological Mechanisms and Precautions of Statins-induced New-onset Diabetes Mellitus[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(2):244-251. |
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| 他汀类药物致新发糖尿病的危险因素、病理机制及防治措施研究进展 |
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顾宇虹1, 宁海宁2, 王金华3, 肖斌2,3, 杜冠华3
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1.鄂尔多斯市卫生健康委员会, 公立医院管理中心, 内蒙古 鄂尔多斯 017000;2.内蒙古医科大学鄂尔多斯临床医学院, 临床药学实验室, 内蒙古 鄂尔多斯 017000;3.中国医学科学院北京协和医学院药物研究所, 药物靶点与新药筛选北京市重点实验室, 北京 100050
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| 摘要: |
| 他汀类药物是一类3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂，目前已广泛应用于冠状动脉粥样硬化性心血管疾病的一级和二级预防。然而长期使用他汀类药物与新发糖尿病的风险具有相关性。研究表明他汀类药物可对胰腺β细胞、周围组织以及相关基因产生影响，进而导致新发糖尿病。本文对他汀类药物致新发糖尿病的危险因素、病理机制及防治措施等方面的研究进展进行综述，以期为该类药物的合理应用、患者的个体化治疗以及相关的基础研究提供参考。 |
| 关键词: 他汀类药物 新发糖尿病 病理机制 危险因素 防治措施 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.02.020 |
| 分类号:R969.3 |
| 基金项目:中国博士后科学基金（2019M650537）；内蒙古自然科学基金资助项目（2017BS0808） |
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| Research Progress on the Risk Factors, Pathological Mechanisms and Precautions of Statins-induced New-onset Diabetes Mellitus |
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GU Yuhong1, NING Haining2, WANG Jinhua3, XIAO Bin2,3, DU Guanhua3
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1.Center for Governmental Hospital Management, Ordos Health Commission, Ordos 017000, China;2.Laboratory of Clinical Pharmacy, Ordos School of Clinical Medicine, Inner Mongolia Medical University, Ordos 017000, China;3.Beijing Key Laboratory of Drug Target Identification and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
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| Abstract: |
| Statins is a kind of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, and have been widely used in primary and secondary prevention of coronary atherosclerotic cardiovascular diseases. However, the risk of new-onset diabetes mellitus is correlated with long-term use of statins. Recent research shows that statins can affect pancreatic β cells, surrounding tissues and related genes, and then lead to new-onset diabetes mellitus. In this paper, research progress on the risk factors, pathological mechanisms and precaution measures of new-onset diabetes mellitus caused by statins are reviewed to provide basis for the rational application of statins, individual treatment of patients and the related basic researches. |
| Key words: statins new-onset diabetes mellitus pathological mechanism risk factor precaution measure |
