| 引用本文: | 邹苏兰,李雅,柳兰,易丽娟,郭志华.正交设计结合G1-熵权法的理气活血方水提工艺研究[J].中国现代应用药学,2021,38(7):769-774. |
| ZOU Sulan,LI Ya,LIU Lan,YI Lijuan,GUO Zhihua.Study on the Extraction Process of Liqi Huoxue Recipe by Orthogonal Design Combined with G1-entropy Weight Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(7):769-774. |
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| 摘要: |
| 目的 优选理气活血方的水提工艺参数。方法 以丹酚酸B、阿魏酸和葛根素转移率及浸膏得率为评价指标，采用L9（34）正交试验设计结合G1-熵权法，以加水量、提取时间和浸泡时间为考察因素，优选出理气活血方的最佳水提工艺参数。结果 理气活血方的最佳水提工艺参数为第1次加10倍量水，浸泡0.5 h，煎煮1.0 h，第2次加8倍量的水，煎煮0.5 h，第3次加8倍量的水，煎煮0.5 h。结论 优选出的理气活血方水提工艺稳定可行。 |
| 关键词: 理气活血方 G1-熵权法 正交设计 丹酚酸B 阿魏酸 葛根素 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.07.001 |
| 分类号:R284.2 |
| 基金项目:国家自然科学基金项目（81673955）；湖南省自然科学基金项目（2017JJ2206）；湖南省中医药科研计划项目重点课题（2020001）；湖南中医药大学中药学一流学科建设项目（4901-0200002006） |
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| Study on the Extraction Process of Liqi Huoxue Recipe by Orthogonal Design Combined with G1-entropy Weight Method |
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ZOU Sulan, LI Ya, LIU Lan, YI Lijuan, GUO Zhihua
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Hunan University of Chinese Medicine, Changsha 410208, China
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| Abstract: |
| OBJECTIVE To optimize the water extraction process parameters of Liqi Huoxue recipe. METHODS Took salvianolic acid B, ferulic acid and puerarin transfer rate and extract yield as evaluation indexes, and the amount of water added, extraction time and soaking time were used as evaluation indicators, L9(34) orthogonal experiment design and G1-entropy method were used to optimize the optimum water extraction process parameters of Liqi Huoxue recipe. RESULTS The optimal water extraction process of Liqi Huoxue recipe were adding 10 times the amount of water for the first time, soaking for 0.5 h, decocting for 1.0 h, adding 8 times the amount of water for the second time, decocting for 0.5 h, and adding 8 times the amount of water for the third time, decocting for 0.5 h. CONCLUSION The optimized water extraction process of Liqi Huoxue recipe is stable and feasible. |
| Key words: Liqi Huoxue recipe G1-entropy weight method orthogonal design salvianolic acid B ferulic acid puerarin |
