| 引用本文: | 李红星,张信岳,武柠子,谷丽丽,鲁佳琪,张玲希,李钦.代谢组学技术在痛风类疾病研究中的应用进展[J].中国现代应用药学,2021,38(1):122-128. |
| LI Hongxing,ZHANG Xinyue,WU Ningzi,GU Lili,LU Jiaqi,ZHANG Lingxi,LI Qin.Application Progress of Metabonomics Technology in the Research of Gout Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(1):122-128. |
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| 代谢组学技术在痛风类疾病研究中的应用进展 |
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李红星1,2, 张信岳1,2, 武柠子1,2, 谷丽丽1,2, 鲁佳琪1,2, 张玲希1,2, 李钦1,2
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1.杭州医学院黄龙科教中心, 杭州 310013;2.浙江省神经精神疾病药物研究重点实验室, 杭州 310013
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| 摘要: |
| 目的 对近年来代谢组学技术在痛风领域的相关研究进行综述，以期为痛风今后更深入的研究提供思路和方向。方法 通过PubMed检索相关文献，分析和总结代谢组学技术在嘌呤代谢、高尿酸血症和痛风相关疾病研究中的应用。结果 代谢组学技术被广泛应用于痛风类疾病的生物标志物发现、发病机制探索以及药物作用机制研究，同时代谢组学技术与其他组学技术结合成为新的研究趋势。结论 代谢组学技术已经成为痛风等人类代谢疾病研究的重要工具，未来将进一步推动痛风类疾病的相关研究。 |
| 关键词: 痛风|嘌呤代谢|高尿酸血症|代谢组学 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.01.020 |
| 分类号:R969.1 |
| 基金项目:浙江省神经精神疾病药物研究重点实验室资助项目（2019E10021）；浙江省中医药科技计划项目（2020ZB038）；浙江省医学科学院院所专项（C12002Y-04） |
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| Application Progress of Metabonomics Technology in the Research of Gout Diseases |
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LI Hongxing1,2, ZHANG Xinyue1,2, WU Ningzi1,2, GU Lili1,2, LU Jiaqi1,2, ZHANG Lingxi1,2, LI Qin1,2
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1.Huanglong Science and Education Center, Hangzhou Medical College, Hangzhou 310013, China;2.Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou 310013, China
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| Abstract: |
| OBJECTIVE To provide ideas and directions for more in-depth research on gout in the future by summarizing the related researches of metabonomics in the field of gout in recent years. METHODS The relevant literatures were searched by PubMed, and the applications of metabonomics in purine metabolism, hyperuricemia and gout-related diseases were analyzed and summarized. RESULTS Metabonomics technology was widely used in the discovery of biomarkers, the exploration of pathogenesis and the study of drug mechanism of gout diseases. In addition, the combination of metabolomics technology and other omics technologies had become a new research trend. CONCLUSION Metabonomics technology has become an important tool for the study of gout and other human metabolic diseases, which will further promote gout-related researches in the future. |
| Key words: gout|purine metabolism|hyperuricemia|metabonomics |
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