1例原发性血小板增多症致颅内静脉窦血栓形成患者的抗血栓治疗分析及药学监护

One Case of Antithrombotic Therapy Selection and Pharmaceutical Care on Patient with Cerebral Venous Sinus Thrombosis Caused by Essential Thrombocythemia

关键词:  颅内静脉窦血栓形成  原发性血小板增多症  抗血栓治疗  药学监护

Key words:  cerebral venous sinus thrombosis  essential thrombocythemia  antithrombotic therapy  pharmaceutical care

摘要:

目的 探讨临床药师在原发性血小板增多症致颅内静脉窦血栓形成患者的抗血栓治疗方案选择以及药学监护中的作用。方法 临床药师参与1例原发性血小板增多症致颅内静脉窦血栓形成患者的药物治疗。治疗期间，临床药师协助医师制定抗血栓治疗方案，为患者制定药学监护计划并实施药学监护，评估药物疗效，监测药物不良反应，开展用药教育。结果 经过抗凝、脱水降颅压、控制癫痫等治疗后，患者无头痛、恶心、呕吐，无肢体抽搐，左侧肢体乏力改善，好转出院。治疗过程中未出现皮肤瘀斑、鼻出血、牙龈出血以及黑便等药物不良反应。结论 临床药师对静脉窦血栓形成患者进行全程的药学监护，可提高药物治疗的有效性、安全性以及患者的依从性。

Abstract:

OBJECTIVE To investigate the role of the clinical pharmacist in pharmaceutical care and antithrombotic therapy selection on a patient with cerebral venous sinus thrombosis caused by essential thrombocythemia. METHODS Clinical pharmacist participated in the whole process of drug treatment for a case of cerebral venous sinus thrombosis related to essential thrombocythemia. During the treatment, the clinical pharmacist gave suggestion on antithrombotic therapy regimen and provided entire pharmaceutical care, evaluated the drug efficacy, monitored drug adverse reaction and carried out medication education. RESULTS The limb weakness of the patient had been improved, without headache, nausea, vomiting and twitch after treated with anticoagulation, dehydration and anti-epileptic. And the patient was discharged. There was no adverse drug reactions during treatment, such as skin and mucous plaque, gingival bleeding, hemorrhinia and melena. CONCLUSION Clinical pharmacists provide pharmaceutical care for patients with cerebral venous sinus thrombosis can promote the efficacy and safety of medication and improve the compliance.