| 引用本文: | 谢静,唐铭擎,丁立生,梁健,李羿.抗COVID-19药物的临床分析研究进展[J].中国现代应用药学,2020,37(6):646-652. |
| XIE Jing,TANG Mingqing,DING Lisheng,LIANG Jian,LI Yi.Progress in Clinical Analysis of Anti-COVID-19 Drugs[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(6):646-652. |
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| 摘要: |
| 洛匹那韦、利托那韦和利巴韦林是《新型冠状病毒感染的肺炎诊疗方案（试行第五版）》的推荐药物。通过研究近年来洛匹那韦、利托那韦和利巴韦林临床药物分析的进展概况，重点关注药物在血浆中的多种测定方法，包括HPLC、LC-MS、MS、分光光度法、毛细管电泳法、免疫法等，为开展治疗药物监测工作提供参考。 |
| 关键词: 新型冠状病毒肺炎 洛匹那韦 利托那韦 利巴韦林 体内药物分析 治疗药物监测 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.06.002 |
| 分类号: |
| 基金项目:国家自然科学基金项目（21572219）；四川省卫生和计划生育委员会科研课题（18PJ549）；抗生素研究与再评价四川省重点实验室开放课题（ARRLKF19-13） |
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| Progress in Clinical Analysis of Anti-COVID-19 Drugs |
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XIE Jing1, TANG Mingqing1,2, DING Lisheng2, LIANG Jian2, LI Yi1
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1.School of Pharmacy, Chengdu Medical College, Chengdu 610500, China;2.Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China
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| Abstract: |
| Lopinavir, ritonavir and ribavirin are recommended in Diagnostic and Treatment Scheme for COVID-19(Trial Version 5). The research progress of clinical drug analysis of lopinavir, ritonavir and ribavirin in recent years is summarized. The focus is on a variety of methods for the determination of drugs in plasma, including HPLC, LC-MS, MS, spectrophotometry, capillary electrophoresis, immunoassay, etc., which provide a reference for the development of therapeutic drug monitoring. |
| Key words: COVID-19 lopinavir ritonavir ribavirin biopharmaceutical analysis therapeutic drug monitoring |
