| 引用本文: | 唐思,董晓茜,杨瑞,靖博宇,张世良,夏素霞,朱婉玲,李国信.生脉注射液3种成分在心肌缺血模型Beagle犬体内的药动学研究[J].中国现代应用药学,2016,33(10):1239-1243. |
| TANG Si,DONG Xiaoqian,YANG Rui,JING Boyu,ZHANG Shiliang,XIA Suxia,ZHU Wanling,LI Guoxin.Pharmacokinetics of 3 Kinds of Active Compounds of Shengmai Injection in Beagle Dogs of Myocardial Ischemia[J].Chin J Mod Appl Pharm(中国现代应用药学),2016,33(10):1239-1243. |
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| 生脉注射液3种成分在心肌缺血模型Beagle犬体内的药动学研究 |
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唐思1, 董晓茜1, 杨瑞1, 靖博宇1, 张世良1, 夏素霞1, 朱婉玲2, 李国信1
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1.辽宁省中医药研究院临床药理实验室, 沈阳 110034;2.辽宁中医药大学药学院, 沈阳 110032
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| 摘要: |
| 目的 研究生脉注射液活性成分人参皂苷Rg1、人参皂苷Re、五味子醇甲在正常和心肌缺血状态下Beagle犬体内的药动学变化。方法 选用Agilent ZORBAX SB-C18色谱柱，流动相为乙腈-水，梯度洗脱，质谱采用选择反应监测（SIM）方式进行正离子检测3种活性成分。用WinNonlin 6.3软件和SPSS 19.0软件计算各给药组药动学参数，并进行统计分析。结果 造模后，人参皂苷Rg1半衰期缩短；人参皂苷Re表观分布容积增大，肾清除率减慢；模型组五味子醇甲半衰期延长，体内平均滞留时间延长，表观分布容积增大，肾清除率减慢。结论 Beagle犬滴注生脉注射液后，人参皂苷Rg1、人参皂苷Re、五味子醇甲在心肌缺血模型犬体内的药动学特征，与正常犬的药动学特征存在很大差异。 |
| 关键词: 生脉注射液 人参皂苷Rg1 人参皂苷Re 五味子醇甲 Beagle犬 药动学 |
| DOI：10.13748/j.cnki.issn1007-7693.2016.10.004 |
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| 基金项目:国家“十二五”重大新药创制项目（2012ZX09303-017）；国家临床重点专科建设项目经费资助（2013年）；国家中医药管理局临床中药学重点学科（2009年）；辽宁中医药大学杏林学者青蓝工程（2013年） |
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| Pharmacokinetics of 3 Kinds of Active Compounds of Shengmai Injection in Beagle Dogs of Myocardial Ischemia |
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TANG Si1, DONG Xiaoqian1, YANG Rui1, JING Boyu1, ZHANG Shiliang1, XIA Suxia1, ZHU Wanling2, LI Guoxin1
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1.Laboratory of Clinical Pharmacy, Academe of Traditional Chinese Medicine of Liaoning Province, Shenyang 110034, China;2.Liaoning Univercity of TCM, Shenyang 110032, China
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| Abstract: |
| OBJECTIVE To study the pharmacokinetics changes of the active compounds of Shengmai injection (including ginsenoside Rg1, ginsenoside Re and schizandrin) in normal and myocardial ischemia Beagle dogs. METHODS Agilent ZORBAX SB-C18 chromatography column was applied. The gradient mobile phase was HCN-H2O system. Ginsenoside Rg1, ginsenoside Re and schizandrin were detected by the positive electrospray ionization method under single ion monitoring (SIM) mode. The pharmacokinetic parameters of different active compounds were analyzed by WinNonlin 6.3 software and SPSS 19.0. RESULTS After modeling, the values of T1/2 of ginsenoside Rg1 showed shorter. The apparent volume of ginsenoside Re showed larger, and the values of renal clearance reduced. The values of T1/2, mean residence time and apparent volume of schizandrin showed higher, while the values of renal clearance of schizandrin reduced. CONCLUSION After injecting Shengmai injection, the pharmacokinetics results obtained from this study show that the pharmacokinetics of ginsenoside Rg1, ginsenoside Re and schizandrin in Beagle dogs of myocardial ischemia are significantly different from normal dogs. |
| Key words: Shengmai injection ginsenoside Rg1 ginsenoside Re schizandrin beagle dogs pharmacokinetics |
