| 引用本文: | 张若英,徐颖颖,郑韧,王怀冲,王宇,蔡鑫君.抗菌药物与洛匹那韦/利托那韦相互作用研究进展[J].中国现代应用药学,2021,38(4):503-507. |
| ZHANG Ruoying,XU Yingying,ZHENG Ren,WANG Huaichong,WANG Yu,CAI Xinjun.Research Progress of Interactions Between Antibacterials and Lopinavir/Ritonavir[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(4):503-507. |
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| 摘要: |
| 口服抗病毒药洛匹那韦/利托那韦的抗病毒作用受很多因素的影响，如患者性别、种族、合并症、用药依从性等。与其他药物的相互作用也是影响洛匹那韦/利托那韦抗病毒的重要因素之一，其中一些抗菌药物对洛匹那韦/利托那韦的影响较大且机制复杂，作用持续时间也较长，对于联用洛匹那韦/利托那韦合并细菌或真菌感染的患者，抗菌药物的选择与监测更为重要。本文通过综述国内外相关研究，探讨和总结洛匹那韦/利托那韦与抗菌药物的相互作用机制和应对策略，比较不同抗菌药物的药动学特性及与洛匹那韦/利托那韦相互作用的差异，从而为抗菌药物的选择和相应剂量的调整提供参考，降低患者用药风险，提高安全性。 |
| 关键词: 抗菌药物 洛匹那韦/利托那韦 相互作用 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.04.022 |
| 分类号:R969.2 |
| 基金项目:浙江省药学会医院药学专项科研资助项目（2019ZYY27）；杭州市医坛新秀培养对象（2020年度） |
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| Research Progress of Interactions Between Antibacterials and Lopinavir/Ritonavir |
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ZHANG Ruoying, XU Yingying, ZHENG Ren, WANG Huaichong, WANG Yu, CAI Xinjun
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Department of Pharmacy, Zhejiang Integrated Traditional and Western Medicine Hospital, Hangzhou 310003, China
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| Abstract: |
| The effectiveness of lopinavir/ritonavir, an oral antiviral drug, was affected by patient's sex, race, presence of comorbidities, adherence. Interactions with other drugs was also one of the important factors affecting the antiviral action of lopinavir/ritonavir, the interactions among lopinavir/ritonavir and some antibacterials were major, complex and delayed. Thus, the choice of antibacterials and concentration monitoring were very important for the patient with bacterial or fungal infections receiving lopinavir/ritonavir treatment. This review summarized the data about the influence of antibacterials on lopinavir/ritonavir treatment and analyzed interaction mechanisms and suggested management to provide reference about choice of antibacterials and dosage adjustment of antibacterials, to avoid the risk of medication and improved safety. |
| Key words: antibacterials lopinavir/ritonavir interaction |
