| 引用本文: | 曹联攻,邵仲柏,蒋凯俊,王有宪,刘书豪,刘玮炜.抗新型冠状病毒潜在药物法匹拉韦研究进展[J].中国现代应用药学,2020,37(7):769-776. |
| CAO Liangong,SHAO Zhongbai,JIANG Kaijun,WANG Youxian,LIU Shuhao,LIU Weiwei.Progress of Favipiravir: The Potential Anti SARS-CoV-2 Drug[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(7):769-776. |
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| 抗新型冠状病毒潜在药物法匹拉韦研究进展 |
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曹联攻1,2,3,4, 邵仲柏4, 蒋凯俊4, 王有宪4, 刘书豪4, 刘玮炜1,2,3,4
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1.江苏海洋生物资源与环境重点实验室, 江苏 连云港 222005;2.江苏海洋大学, 江苏省海洋药物活性分子筛选重点实验室, 江苏 连云港 222005;3.江苏省海洋生物产业技术协同创新中心, 江苏 连云港 222005;4.江苏海洋大学药学院, 江苏 连云港 222005
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| 摘要: |
| 2019年新型冠状病毒肺炎疫情暴发，病毒感染威胁极大，法匹拉韦是作用机制新颖的广谱抗病毒药物，作为抗新型冠状病毒感染的潜在药物，目前正在开展相关临床试验。本文综述了法匹拉韦的结构、作用机制、药动学、抗病毒活性以及合成方法研究进展，希望能为抗病毒治疗提供参考。 |
| 关键词: 法匹拉韦 机制 抗病毒活性 合成 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.07.001 |
| 分类号:R961 |
| 基金项目:江苏省高校优势学科建设工程资助项目（PAPD）；江苏省研究生科研与实践创新计划项目（KYCX19-2277，KYCX19-2281）；连云港市“521工程”资助项目（LYG52105-2018023） |
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| Progress of Favipiravir: The Potential Anti SARS-CoV-2 Drug |
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CAO Liangong1,2,3,4, SHAO Zhongbai4, JIANG Kaijun4, WANG Youxian4, LIU Shuhao4, LIU Weiwei1,2,3,4
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1.Jiangsu Key Laboratory of Marine Bioresources and Environment, Lianyungang 222005, China;2.Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang 222005, China;3.Co-innovation Center of Jiangsu Marine Bio-industry Technology, Lianyungang 222005, China;4.School of Pharmacy, Jiangsu Ocean University, Lianyungang 222005, China
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| Abstract: |
| The outbreak of COVID-19 poses a great threat to human. Favipiravir is a broad-spectrum antiviral drug with a novel mechanism. As a potential drug against SARS-CoV-2, favipiravir is currently conducting clinical trials. This article reviews the structure, mechanism, pharmacokinetics, antiviral activity and synthetic methods of fapilavir, in order to provide a reference for antiviral therapy. |
| Key words: favipiravir mechanism antiviral activity synthesis |
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