预调配模式在静脉用药调配中心的应用优化及质量控制体系构建

Optimization for Pre-admixture Mode in Pharmacy Intravenous Admixture Services and Establishment of Quality Control System

关键词:  预调配模式  配液泵  静脉用药调配中心  优化  质量控制

Key words:  pre-admixture mode  pump  pharmacy intravenous admixture services  optimization  quality control

摘要:

目的 优化影响预调配模式调配质量的关键操作点，以优化后的关键点作为质量控制的关键指标，构建预调配模式的质量控制体系。方法 找出影响预调配模式调配质量的关键点，包括精准度、成品输液的核对方式、配液泵的残留。通过对排气泡、校准和灌注体积确定方式的改进，保障配液泵的精准度和成品输液的精准度，优化成品输液核对方式。测定配液泵的残留情况，检验其是否符合限定标准。结果 优化了影响预调配模式调配质量的关键操作点，以这些关键点作为质量控制构建的关键指标，同时规范了无菌调配操作、储备液的存放条件以及预调配模式全过程的标准化。结论 在优化预调配模式应用的过程中得到了其质量控制的关键指标，在此基础上，将构建预调配模式在静脉用药调配中心的质量控制体系。

Abstract:

OBJECTIVE To establish the quality control system of pre-admixture mode by using the key operations which have influences on drugs admixture by pre-admixture mode after optimization as the key indexs in quality control. METHODS The key operations which had influences on drugs admixture by pre-admixture mode had been found, which including accuracy, the way of checking finished infusion and the residue produced by pump. Through the optimization of the way of draining bubbles, calibration and pumping volume to guarantee the accuracy of pump and finished infusion. The way of checking finished infusion was improved. The residue produced by pump was detected to judge whither it met the standard or not. RESULTS The key operations having influences on drugs admixture by pre-admixture mode were improved. Using these key operations as key indexes to establish the quality control system, and other indexes, including aseptic admixture operation, storage condition of stock solution and standardization of all operations in pre-admixture mode were normalized. CONCLUSION The key indexes of quality control system have been got in the process of the optimization, and the quality control system of pre-admixture mode will established on this basis in pharmacy intravenous admixture services.