基于数据挖掘的含藏药材日官孜玛方剂组方及用药规律研究

Study on the Prescription and Medication Rule of Prescription Contain Tibetan Herbal Medicine Corydalis Hendersonii Based on Data Mining

关键词:  藏药  日官孜玛  尼泊尔黄堇  矮紫堇  用药规律

Key words:  Tibetan medicine  Corydalis hendersonii  Corydalis hendersonii Hemsl.  Corydalis Herba  compatibility rule

摘要:

目的 研究藏药材日官孜玛的用药规律及含该药材方剂的配伍规律，为临床用药及潜在新处方的发现提供参考。方法 采用Apriori算法和社区模块化等数据挖掘方法，分析含日官孜玛方剂中各味药材的配伍规律和高频主治疾病用药规律。结果 共收集含日官孜玛方剂109首，涉及364味藏药材，通过频次统计分析发现日官孜玛多与清热止痛、活血行"隆"类药物联合使用，主治疾病为"培根木布"病、热泻病和瘟疫等藏医病种。关联规则分析得出频数、支持度、置信度均最高的药物组合日官孜玛-兔耳草、日官孜玛-诃子和日官孜玛-渣驯，体现了藏药方剂的"主辅配伍"规律。含日官孜玛方剂治疗"培根木布"病、热泻病和瘟疫等疾病时多与清热行"隆"、止泻止血、除瘟解毒等药物配伍使用，且各方剂的配伍具有明显差异性，符合藏药方剂学"君臣将士"配伍用药规律。结论 含藏药材日官孜玛方剂组方规律明确，主治疾病与核心药物组合相互对应，符合藏药方剂学的"君臣将士"配伍规律，表明该规律为代表的藏医方剂理论在藏药复方新药开发和临床个性化用药中具有重要的指导意义。研究结果为临床合理使用日官孜玛及含日官孜玛方剂提供了重要参考依据。

Abstract:

OBJECTIVE To provide reference for clinical medication and the development of potential new prescriptions through study the medicinal rules of Tibetan herbal medicine Corydalis hendersonii and the compatibility of prescriptions containing this herb. METHODS The compatibility rule of prescriptions containing Corydalis hendersonii and the rule of medication for high-frequency diseases was analyzed by used data mining methods such as Apriori algorithm and community modularization. RESULTS A total of 109 kinds of prescriptions contained Corydalis hendersonii were collected, containing 364 kinds of Tibetan herbal medicines. It was found that Corydalis hendersonii was mostly used in combination with heat-clearing and analgesic herbs, and activate blood circulation herbs and run long herbs through the frequency statistical analysis. Prescriptions contained Corydalis hendersonii were mainly treated Tibetan diseases such as "Peigen Mubu", heat diarrhea and plague, et al. The Tibetan herbal medicine combination with the highest frequency and degree of support and confidence was Corydalis hendersonii-Lagotis brachystachya, Corydalis hendersonii-Terminalia chebula, and Corydalis hendersonii-Zhaxun, it embodied the "main and auxiliary compatibility" rule of Tibetan medicine prescriptions. Corydalis hendersonii were often used in combination with heat-reducing and run long herbs, antidiarrheal herbs, hemostatic herbs, anti-epidemic herbs and detoxifying herbs in the treatment of "Peigen Mubu" diseases, heat diarrhea diseases and plague. In addition, there were obvious differences in the compatibility of the various prescriptions, which was in line with the rule of "monarch-minister-general-warrior" in Tibetan medicine prescriptions. CONCLUSION The prescriptions containing Corydalis hendersonii have clear characteristics, and the diseases are closely related to the drug combination, which is in line with the rule of "monarch-minister-general-warrior" in Tibetan medicine prescriptions. It shows that this rule has important guiding significance in the development of potential new prescriptions and clinical personalized medicine. The research results can provide important references for the rational use of Corydalis hendersonii and prescriptions containing Corydalis hendersonii.