自拟益气健脾化湿方治疗脾虚湿蕴型溃疡性结肠炎缓解期临床效果研究

Study on Clinical Effect of Self-designed Yiqi Jianpi Huashi Decoction in the Remission Stage of Ulcerative Colitis with Spleen Deficiency and Damp Deposition Type

关键词:  益气健脾化湿方  脾虚湿蕴型  溃疡性结肠炎  临床疗效

Key words:  Yiqi Jianpi Huashi decoction  spleen deficiency and dampness accumulation type  ulcerative colitis  clinical efficacy

摘要:

目的 探讨自拟益气健脾化湿方治疗脾虚湿蕴型溃疡性结肠炎缓解期的临床疗效。方法 将2017年12月—2019年12月在浙江省立同德医院进行治疗的120例脾虚湿蕴型溃疡性结肠炎缓解期患者纳入研究，按照就诊时间采用随机、双盲、平行对照的方法，通过简单随机分组分为观察组和对照组，每组60例。对照组应用美沙拉嗪肠溶片治疗，观察组应用自拟益气健脾化湿方治疗，治疗周期均为12周，随访观察2组患者治疗前后中医症候评分、生存质量（SF-36）及总的临床治疗效果，并对治疗期间出现的不良反应进行总结分析。结果 治疗后，观察组中医症候评分、SF-36评分显著高于对照组，差异有统计学意义（P<0.05）；观察组患者治疗总有效率为93.33%，对照组为73.33%，观察组显著高于对照组（P<0.05），治疗期间均未出现严重不良反应。结论 自拟益气健脾化湿方治疗脾虚湿蕴型溃疡性结肠炎缓解期患者疗效确切，显著改善患者腹泻、腹胀、腹痛、脓血便等主症，进一步提高生活质量，且治疗过程中未见严重药物不良反应，临床应用前景广阔。

Abstract:

OBJECTIVE To explore the clinical efficacy of self-formulated Yiqi Jianpi Huasi decoction in the remission stage of ulcerative colitis with spleen deficiency and dampness accumulation type. METHODS A total of 120 patients with ulcerative colitis with spleen deficiency and dampness accumulation type treated in Tongde Hospital of Zhejiang Province from December 2017 to December 2019 were included in the study, and randomly divided into observation group and control group with 60 cases in each group according to the time of visit. The control group was treated with mesalazine enteric-coated tablet, and the observation group was treated with self-designed Yiqi Jianpi Huashi decoction, the treatment period was 12 weeks. The TCM symptom score, quality of life(SF-36) and the total clinical treatment effect of patients in the two groups were observed before and after treatment, and the adverse reactions during treatment were summarized and analyzed. RESULTS After treatment, TCM syndrome score and SF-36 score in the observation group were significantly higher than those in the control group, the differences were statistically significant(P<0.05). The total effective rate in the observation group was 93.33%, and that in the control group was 73.33%, which was significantly higher in the observation group than that in the control group(P<0.05). No serious adverse reactions occurred during the treatment. CONCLUSION The self-designed Yiqi Jianpi Huashi decoction is effective in the remission stage of ulcerative colitis with spleen deficiency and dampness accumulation type, which can significantly improve the main symptoms such as diarrhea, abdominal distension, abdominal pain, pus and blood stool, and further improve the quality of life. Besides, no serious adverse drug reactions have been observed in the treatment process, and the clinical application prospect is broad.