| 引用本文: | 韩晓阳,陈悦,杨洋,徐薇,卫林.表没食子儿茶素没食子酸酯的抗感染作用研究进展[J].中国现代应用药学,2021,38(20):2616-2620. |
| HAN Xiaoyang,CHEN Yue,YANG Yang,XU Wei,WEI Lin.Advances in the Anti-infective Effects of Epigallocatechin Gallate[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(20):2616-2620. |
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| 表没食子儿茶素没食子酸酯的抗感染作用研究进展 |
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韩晓阳1, 陈悦1, 杨洋2, 徐薇2, 卫林2
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1.苏州大学, 基础医学与生物科学学院, 江苏 苏州 215123;2.苏州大学, 生物医学研究院, 江苏 苏州 215123
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| 摘要: |
| 表没食子儿茶素没食子酸酯（epigallocatechin gallate，EGCG）是茶多酚的主要组成成分。EGCG具有多种生物学功能，包括抗细菌、抗真菌、抗病毒、抗肿瘤、抗炎症、抗衰老、抗肥胖、抗糖尿病、心血管疾病的预防和保护、免疫调节、神经保护等生物学功能。本文主要归纳了EGCG在治疗新型冠状病毒（SARS-CoV-2）感染中的潜在作用，在耐药细菌感染中的预防和治疗作用，以期为EGCG在抗感染药物开发方面提供一定的理论依据。 |
| 关键词: 表没食子儿茶素没食子酸酯 新型冠状病毒 耐药细菌 预防作用 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.20.025 |
| 分类号:R969.3 |
| 基金项目:国家自然科学基金项目（31870868）；苏州大学第二十二批大学生课外学术科研基金（KY20200904B） |
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| Advances in the Anti-infective Effects of Epigallocatechin Gallate |
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HAN Xiaoyang1, CHEN Yue1, YANG Yang2, XU Wei2, WEI Lin2
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1.Soochow University, School of Biology & Basic Medical Science, Soochow 215123, China;2.Soochow University, Institutes of Biology and Medical Sciences, Soochow 215123, China
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| Abstract: |
| Epigallocatechin gallate(EGCG) is the main component of tea polyphenols. EGCG exhibited diverse biological functions, such as anti-bacterial, anti-fungal, anti-viral, anti-tumor, anti-inflammatory, anti-aging, anti-obesity, anti-diabetic, cardiovascular disease prevention and protection, immune regulation, and neuroprotection. The article mainly summarized the potential role of EGCG in the treatment of new coronavirus(SARS-CoV-2) infections, preventive effects in(drug-resistant) bacterial infections, as well as therapeutic effects in drug-resistant bacterial infections to provide a theoretical basis for EGCG in the development of clinical anti-infective drugs. |
| Key words: epigallocatechin gallate SARS-CoV-2 drug-resistant bacteria preventive effect |
