| 引用本文: | 吴雨珊,宋依杰,王冰.放射性肠炎的病理机制、治疗策略及药物研究进展[J].中国现代应用药学,2022,39(2):277-284. |
| WU Yushan,SONG Yijie,WANG Bing.Research Progress on Pathological Mechanism, Therapeutic Strategy and Drug of Radiation Enteritis[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(2):277-284. |
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| 摘要: |
| 放射性肠炎是腹盆腔或腹膜后肿瘤放射治疗导致的肠道最严重、最常见的并发症之一。受累肠道病变广泛，病理表现复杂，严重影响癌症患者放疗后的生活质量，然而目前临床药物治疗手段较少、效果不佳，相关基础研究和新药开发尚不明朗。本文综述近20年相关文献，对放射性肠炎的病理机制、治疗策略及药物研究进展进行归纳与分析，以期为研究放射性肠炎预防与治疗策略及药物提供思路和方向。 |
| 关键词: 放射性肠炎 病理机制 药物治疗 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.02.023 |
| 分类号:R961 |
| 基金项目:上海市科委自然基金项目(21ZR1475200) |
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| Research Progress on Pathological Mechanism, Therapeutic Strategy and Drug of Radiation Enteritis |
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WU Yushan1,2, SONG Yijie3, WANG Bing2
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1.College of Science, Shanghai University, Shanghai 200444, China;2.Center for Pharmaceutics Research, Shanghai Institute of Materia Media, Chinese Academy of Sciences, Shanghai 201203, China;3.School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
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| Abstract: |
| Radiation enteritis is one of the most serious and frequent complications of the bowel caused by radiation therapy of abdominopelvic or retroperitoneal tumors. The involved intestinal lesions are extensive, and the pathological manifestations are complex, which seriously affects the quality of life for cancer patients after radiotherapy. However, there are fewer and less effective clinical drug treatments and the related basic research, and new drug development are unclear. This paper reviewed the relevant literatures of the past 20 years, summarized and analyzed the pathological mechanism, treatment strategies and drug research progress of radiation enteritis, in order to provide ideas and directions for the research of prevention and treatment strategies and drugs of radiation enteritis. |
| Key words: radiation enteritis pathological mechanism medication |
