| 引用本文: | 张秀芳,张静宜,刘明松,李春花.基于熵权法与响应面法优化香连和胃汤挥发油提取工艺[J].中国现代应用药学,2022,39(14):1848-1855. |
| ZHANG Xiufang,ZHANG Jingyi,LIU Mingsong,LI Chunhua.Optimization of the Extraction Process of Volatile Oil from Xianglian Hewei Soup Based on Entropy Weight Method and Response Surface Method[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(14):1848-1855. |
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| 基于熵权法与响应面法优化香连和胃汤挥发油提取工艺 |
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张秀芳1, 张静宜2,3, 刘明松1, 李春花1,3,4,5
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1.河北中医学院药学院, 石家庄 050090;2.河北省中医院药学部, 石家庄 050000;3.河北省中药制剂产业技术研究院, 石家庄 050090;4.河北省中药组方制剂技术创新中心, 石家庄 050090;5.河北省高校中药组方制剂应用技术研发中心, 石家庄 050090
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| 摘要: |
| 目的 筛选香连和胃汤中挥发油的最优提取工艺及包合工艺，提高挥发油的利用率。方法 以主要成分百秋李醇、桉油精、乙酸龙脑酯以及挥发油得率为指标，采用GC法测定有效成分含量，DX8trial软件设计试验方案，熵权法处理实验数据，最终筛选出挥发油最佳提取工艺；采用研磨法对挥发油进行包合，通过正交试验设计包合方案，逐一记录挥发油包合率、包合物收得率及包合物含油率3个指标，熵权法对指标进行权重分析，根据权重系数计算3个指标的综合评分，并筛选出最佳包合工艺。结果 挥发油最佳提取工艺：浸泡时间1.5 h，提取时间8 h，加水量为8倍水。最佳包合工艺：采用研磨法进行制备，β-CD-挥发油为6︰ 1，料液比为6︰ 1，研磨时间为0.5 h。结论 通过试验筛选的挥发油最佳提取工艺能提高香连和胃汤中挥发油的得率及有效成分含量，筛选所得最佳包合工艺，能有效包合香连和胃汤中的挥发油。 |
| 关键词: 香连和胃汤 挥发油 响应面法 正交试验 包合工艺 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.14.009 |
| 分类号:R285.5 |
| 基金项目:河北省重点研发计划项目(19272502D) |
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| Optimization of the Extraction Process of Volatile Oil from Xianglian Hewei Soup Based on Entropy Weight Method and Response Surface Method |
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ZHANG Xiufang1, ZHANG Jingyi2,3, LIU Mingsong1, LI Chunhua1,3,4,5
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1.College of Pharmacy, Hebei University of Traditional Chinese Medicine, Shijiazhuang 050090, China;2.Department of Pharmacy, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang 050000;3.Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang 050090, China;4.Hebei Technology Innovation Center of TCM Formula Preparations, Shijiazhuang 050090, China;5.Hebei Province College Chinese Medicine Group Formulation Application Technology R&D Center, Shijiazhuang 050090, China
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| Abstract: |
| OBJECTIVE The optimal extraction process and inclusion process of volatile oil in Xianglian Hewei soup were selected to improve the utilization rate of volatile oil. METHODS The index was based on the content of the main ingredients patchouli alcohol, cineole, bomyl acetate and the yield of volatile oil, the GC method was used to determine the content of active ingredients, the DX8trial designed the test plan, and the entropy weight method was used to process the experimental data, and finally screened out the best extraction process for volatile oil. Used grinding method to clathrate volatile oil, and the inclusion scheme was designed through orthogonal experiments, and record 3 indicators of volatile oil inclusion rate, inclusion compound yield and inclusion compound oil rate one by one. The entropy weight method was used to perform the index Weight analysis, calculate the comprehensive score of the three indicators according to the weight coefficient, and screen out the best inclusion technology. RESULTS The best extraction process for volatile oil was immersion time of 1.5 h, extraction time of 8 h, and the amount of water added of 8 times water. The best inclusion process was as follows:prepared by grinding method, β-CD-volatile oil was 6︰ 1, material liquid ratio was 6︰ 1 and the grinding time was 0.5 h. CONCLUSION The best extraction process of volatile oil selected by the experiment can increase the yield of volatile oil and the content of active ingredients in Xianglian Hewei soup, and the best inclusion technology obtained by screening can effectively include the volatile oil in Xianglian Hewei soup. |
| Key words: Xianglian Hewei soup volatile oil response surface methodology orthogonal test inclusion process |
