| 引用本文: | 陈应芳,樊莎莎,史云娟,孙铭辰,应晓英,潘卫利,陶小华.基于D-α维生素E聚乙二醇琥珀酸酯的纳米载体在皮肤疾病治疗中的研究进展[J].中国现代应用药学,2022,39(8):1105-1109. |
| CHEN Yingfang,FAN Shasha,SHI Yunjuan,SUN Mingchen,YING Xiaoying,PAN Weili,TAO Xiaohua.Research Progress of Nanocarriers Based on D-a Tocopherol Polyethylene Glycol Succinate in the Treatment of Skin Diseases[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(8):1105-1109. |
|
| 本文已被：浏览 1543次 下载 958次 |
码上扫一扫！ |
|
|
| 基于D-α维生素E聚乙二醇琥珀酸酯的纳米载体在皮肤疾病治疗中的研究进展 |
|
陈应芳1, 樊莎莎2, 史云娟1, 孙铭辰3, 应晓英3, 潘卫利2, 陶小华1,2
|
|
1.蚌埠医学院研究生院, 安徽 蚌埠 233000;2.浙江省人民医院, 杭州 310014;3.浙江大学药学院, 杭州 310058
|
|
| 摘要: |
| 皮肤相关疾病的发病率逐年增加，大部分皮肤疾病的治疗以外用制剂为主，但存在透皮率低、稳定性差等问题。D-α维生素E聚乙二醇琥珀酸酯(D-α-tocopherol polyethylene glycol succinate，TPGS)具有聚乙二醇与维生素E的双重功能，在药物递送系统中可作为增溶剂、促渗剂、乳化剂、稳定剂，用于提高药物的溶解度、稳定性、包封率、载药量及透皮吸收率等。本文对TPGS的理化性质、其作为药用辅料的应用、在纳米载体系统中的应用及基于TPGS的纳米载体在皮肤疾病治疗中的研究等进行综述，以期为开发治疗皮肤相关疾病的新型TPGS纳米载体提供参考。 |
| 关键词: D-α维生素E聚乙二醇琥珀酸酯 药物辅料 纳米载体 皮肤疾病 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.08.016 |
| 分类号:R943 |
| 基金项目:国家自然科学基金项目(81771962)；浙江省基础公益研究计划项目(LGF20H110003) |
|
| Research Progress of Nanocarriers Based on D-a Tocopherol Polyethylene Glycol Succinate in the Treatment of Skin Diseases |
|
CHEN Yingfang1, FAN Shasha2, SHI Yunjuan1, SUN Mingchen3, YING Xiaoying3, PAN Weili2, TAO Xiaohua1,2
|
|
1.Graduate School of Bengbu Medical College, Bengbu 233000, China;2.Zhejiang Provincial People's Hospital, Hangzhou 310014, China;3.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
|
| Abstract: |
| The incidence of skin-related diseases is increasing year by year, most skin diseases are mainly treated with preparations, but there are some problems such as low transdermal rate and poor stability. D-α-tocopherol polyethylene glycol succinate(TPGS) has the dual functions of polyethylene glycol and vitamin E, and can be used as solubilizer, penetration enhancer, emulsifier and stabilizer in drug delivery system. TPGS has also been widely used to improve the solubility, stability, encapsulation rate, drug loading and transdermal absorption rate of drugs. In this paper, the physical and chemical properties of TPGS, the application of TPGS as pharmaceutical excipients, the application of TPGS in nanocarrier system and the application of TPGS nanocarrier in the treatment of skin diseases are reviewed, so as to provide reference for the development of new TPGS nanocarriers for the treatment of skin-related diseases. |
| Key words: D-a tocopherol polyethylene glycol succinate(TPGS) pharmaceutical excipients nano-carrier skin diseases |
