二十碳五烯酸乙酯胶囊降低缺血性心血管事件的研究进展

Research Progress of Icosapent Ethyl in Reducing Ischemic Cardiovascular Events

关键词:  二十碳五烯酸乙酯胶囊  甘油三酯  缺血性心血管事件

Key words:  icosapent ethyl  triglycerides  ischemic cardiovascular events

摘要:

动脉粥样硬化性心血管疾病发病率逐渐上升，并呈年轻化趋势。血脂异常是动脉粥样硬化发生和进展的重要危险因素。其中甘油三酯水平升高是缺血性心血管事件风险增加的独立危险因素。既往降甘油三酯药物：贝特类、烟酸和混合ω-3多不饱和脂肪酸无明确减少缺血性心血管事件发生的作用，近年研究发现二十碳五烯酸乙酯胶囊除了可降低甘油三酯水平外，同时还可通过延缓斑块进展、减小低衰减斑块体积、稳定斑块形态等机制降低缺血性心血管事件的发生率。目前完成的动物实验和临床试验均证明了其有效性、安全性和良好的耐受性。本文主要对二十碳五烯酸乙酯胶囊降低缺血性心血管事件研究的新进展进行综述。

Abstract:

The incidence of atherosclerotic cardiovascular disease is gradually increasing, and is showing a younger trend. Dyslipidemia is an important risk factor for the occurrence and progression of atherosclerosis. Among them, elevated triglyceride level is an independent risk factor for increased risk of ischemic cardiovascular events. Previous triglyceride lowering drugs:fibrates, niacin and mixed omega-3 polyunsaturated fatty acids have no clear effect on reducing ischemic cardiovascular events. Recent studies have found that icosapent ethyl could reduce triglyceride levels and also it could reduce the incidence of ischemic cardiovascular events through mechanisms such as delaying plaque progression, reducing low-attenuation plaque volume and stabilizing plaque morphology. Currently completed animal experiments and clinical trials have proved its effectiveness, safety and good tolerability. This article mainly reviews the new progress of icosapent ethyl in reducing ischemic cardiovascular events.