乙酰左旋肉碱抗氧化功能及机制的研究进展

Research Progress on Antioxidant Function and Mechanism of Acetyl L-carnitine

关键词:  氧化应激  乙酰左旋肉碱  抗氧化功能  抗氧化机制  信号通路  临床治疗

Key words:  oxidative stress  acetyl L-carnitine  antioxidant function  antioxidant mechanism  signal pathway  clinical treatment

摘要:

氧化应激是造成诸多神经退行性疾病的主要原因之一,它会导致线粒体功能异常,抗氧化酶活性降低,加速细胞的衰老和凋亡。乙酰左旋肉碱(acetyl L-carnitine,ALC)作为天然的抗氧化剂,已被证实与线粒体的能量代谢有关,可以通过清除过量自由基,提升抗氧化酶活性,维持线粒体功能正常运转,提供能量等方式来抑制氧化应激状态,并且通过调控氧化应激相关蛋白以及Keap-Nrf2/ARE、Wnt/β-catenin信号通路来保护机体。在临床应用上已被用来研究治疗帕金森病、阿尔茨海默病、糖尿病等疾病。本文对ALC在抗氧化方面的最新研究进展进行综述。

Abstract:

Oxidative stress is one of the main causes of many neurodegenerative diseases, which can lead to abnormal mitochondrial function, decrease the activity of antioxidant enzymes, and accelerate cell senescence and apoptosis. As a natural antioxidant, acetyl L-carnitine(ALC) has been proved to be related to the energy metabolism of mitochondria. It can inhibit the state of oxidative stress by scavenging excessive free radicals, increasing the activity of antioxidant enzymes, maintaining the normal operation of mitochondria and providing energy. And protect the body by regulating oxidative stress-related proteins and Keap-Nrf2/ARE, Wnt/β-catenin signal pathway. In clinical application, it has been used to study and treat Parkinson's disease, Alzheimer's disease, diabetes and other diseases. This article reviewed the latest research progress of ALC in antioxidation.