| 引用本文: | 郭鼎睿,刘彬彬,张婷婷,王君,邹黎黎.二氢卟吩e6及其对肿瘤的光动力疗法的研究进展[J].中国现代应用药学,2022,39(14):1908-1916. |
| GUO Dingrui,LIU Binbin,ZHANG Tingting,WANG Jun,ZOU Lili.Research Progress of Chlorin E6 and Its Photodynamic Therapy on Tumor[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(14):1908-1916. |
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| 二氢卟吩e6及其对肿瘤的光动力疗法的研究进展 |
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郭鼎睿1,2, 刘彬彬1,2, 张婷婷1,2, 王君1,2, 邹黎黎1,2
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1.三峡大学医学院, 肿瘤微环境与免疫治疗湖北省重点实验室, 湖北 宜昌 443000;2.三峡大学医学院, 感染与炎症损伤研究所, 湖北 宜昌 443000
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| 摘要: |
| 光动力疗法(photodynamic therapy， PDT)是一种利用光能及活性氧清除肿瘤组织的新兴无侵入性微创光生物活性治疗策略。特定波长的光、光敏剂和活性氧是 PDT 的基础，其中最关键的因素是光敏剂。由于吸光系数大，作用深，体内残留少及安全性高等优点，二氢卟吩类光敏剂受到医学领域的广泛认可。二氢卟吩 e6(chlorin e6， Ce6)作为其中的领军成员，尽管清除肿瘤效能高，但潜在的低靶向性及耐药性也阻碍着应用前景。因此，科研工作者们近年将精力投入到将功能性基团引入到 Ce6 结构中，或使用高新纳米技术，以求提高其肿瘤特异性与药物靶向性，并取得了良好的实验进展。本文就近年来光敏剂的发展史及重要光敏剂 Ce6 对肿瘤的光动力疗法的相关研究进展做一综述。 |
| 关键词: 二氢卟吩e6 光动力治疗 光敏剂 恶性肿瘤 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.14.019 |
| 分类号:R73 |
| 基金项目:国家自然科学基金项目(81903105，32170191) |
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| Research Progress of Chlorin E6 and Its Photodynamic Therapy on Tumor |
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GUO Dingrui1,2, LIU Binbin1,2, ZHANG Tingting1,2, WANG Jun1,2, ZOU Lili1,2
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1.China Three Gorges University, Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Yichang 443000, China;2.China Three Gorges University, Institute of Infection and Inflammation, Yichang 443000, China
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| Abstract: |
| Photodynamic therapy(PDT) is an emerging non-invasive minimally traumatic photobiological activity therapy strategy that uses light and reactive oxygen species to remove tumor tissue. Light, photosensitizer and reactive oxygen species are the basis of PDT, among which photosensitizer is the most critical factor. Porphin has been widely recognized in the medical domain due to its advantages of large light absorptivity, deep action depth, less residue in vivo and high safety. Chlorin e6(Ce6), as a leading member of Porphin, has high efficacy in tumor clearance; however, its potentially off-target and drug resistance hinder its development. Therefore, in recent years, researchers have focused on introducing functional groups into the structure of Ce6 or using high-tech nanotechnology to improve its tumor specificity and drug targeting and have achieved good results. This article reviews the development history of photosensitizers in recent years and the related research progress of the important photosensitizer Ce6 on tumor photodynamic therapy. |
| Key words: chlorin e6 photodynamic therapy photosensitizer tumor |
