桂利嗪片与哌醋甲酯缓释片配伍的抗运动病药效研究

Study on the Efficacy of Combination of Cinnarizine Tablets and Methylphenidate Against Motion Sickness

关键词:  运动病  旋转刺激  比格犬  桂利嗪片  哌醋甲酯缓释片  茶苯海明片

Key words:  motion sickness  rotatory stimulation  Beagle dog  cinnarizine tablets  methylphenidate  dimenhydrinate tablets

摘要:

目的 研究桂利嗪片与哌醋甲酯缓释片配伍的抗运动病效果。方法 人体实验检测8名男性受试者接受旋转刺激后的眼震电图变化；动物实验采用20条比格犬，以复合旋转刺激模式诱发其产生流涎、呕吐症状，比较各组动物的流涎、呕吐潜伏期。结果 受试者单独服用桂利嗪片或哌醋甲酯缓释片，或合用桂利嗪片与哌醋甲酯缓释片，在服药后1，2，4 h均能抑制旋转刺激诱导的眼震持续时间和平均慢相速度，但桂利嗪片与哌醋甲酯缓释片配伍的效果更强。比格犬药物处理后，阳性对照药物茶苯海明组、桂利嗪片与哌醋甲酯缓释片配伍的小剂量组流涎、呕吐潜伏期较对照组有延长趋势，但差异无统计学意义，而桂利嗪片与哌醋甲酯缓释片配伍的中剂量组和高剂量组流涎、呕吐潜伏期较对照组明显延长，且中剂量组流涎、呕吐潜伏期明显长于茶苯海明组。结论 桂利嗪片与哌醋甲酯缓释片配伍具有明显的抗运动病作用，且效果可能优于茶苯海明片。

Abstract:

OBJECTIVE To investigate the anti-motion sickness efficacy of combination of cinnarizine tablets and methylphenidate. METHODS Changes in the electronystagmogram parameters of 8 male volunteers were recorded after rotatory stimulation. Twenty Beagle dogs were used in the animal experiment to induce salivation and vomiting symptoms by using a compound rotational stimulation pattern, and the latency of salivation and vomiting in each group of animals was compared. RESULTS The subjects took cinnarizine tablets or methylphenidate alone, or took cinnarizine tablets or methylphenidate in combination, which could inhibit the duration of rotational stimulation-induced nystagmus and the average slow-phase velocity at 1, 2, and 4 h after medication, and the efficacy of combined use of cinnarizine table and methylphenidate was stronger than that of cinnarizine table or methylphenidate alone. After the beagle dogs were treated with drugs, the latency of salivation and vomiting in the positive control drug diphenhydramine group and the low-dose group of narizine combined with methylphenidate was longer than that in the control group, but without statistical significance compared with the control group. However, the salivation and vomiting latencies treated with a medium-dose or a high-dose of combination of cinnarizine table and methylphenidate were significantly longer than control group, and the salivation and vomiting latencies of the medium-dose group were significantly longer than dimenhydrinate group. CONCLUSION The combination of cinnarizine tablets and methylphenidate reveals a significant anti-motion sickness effect, which maybe better than that of dimenhydrinate tablets.