芒柄花素对围绝经期女性的药用价值研究

Medicinal Value Research of Formononetin for Perimenopausal Women

关键词:  芒柄花素  围绝经期  抗肿瘤  临床作用

Key words:  formononetin  perimenopausal  anti-tumor  clinical effect

摘要:

针对女性围绝经期综合征，传统采用雌激素替代疗法(hormone replacement therapy，HRT)进行治疗，但长期采用HRT可增加发生阴道出血、乳腺癌及子宫内膜癌等疾病的风险。因此相对安全有效的植物雌激素越来越受到人们的关注。芒柄花素(formononetin，FMN)作为天然来源的异黄酮类植物雌激素，具有抗肿瘤、抗氧化、抗炎、调节免疫、雌激素样及调节肠道菌群等多种作用，能防治骨质疏松、糖尿病和心脑血管疾病，对于改善女性卵巢功能减退导致的围绝经期症状具有重要意义。本文针对FMN的药用价值对于改善围绝经期女性相关症状方面进行综述，为FMN的应用提供参考。

Abstract:

Hormone replacement therapy(HRT) is used to treat perimenopausal women traditionally. However, prolonged use of HRT can increase the risk of vaginal bleeding, breast cancer and endometrial cancer. Therefore, the relatively safe and effective phytoestrogen has attracted more and more attention. Formononetin(FMN), as a naturally isoflavone phytoestrogens, has a variety of effects, such as anti-tumor, anti-oxidation, anti-inflammatory, regulating immunity, estrogen like and regulating intestinal flora. It can prevent osteoporosis, diabetes, cardiovascular and cerebrovascular diseases. Formononetin is significant for women to improve the perimenopausal symptoms caused by ovarian dysfunction. This paper reviews the medicinal value of FMN in improving the related symptoms of perimenopausal women, so as to provide reference for the application of FMN.