| 引用本文: | 方胡凤,徐姗,龚金红,唐丽丹,钱晓丹,苏丹.透明质酸在抗菌制剂中的应用进展[J].中国现代应用药学,2022,39(16):2158-2164. |
| FANG Hufeng,XU Shan,GONG Jinhong,TANG Lidan,QIAN Xiaodan,SU Dan.Application Progress of Hyaluronic Acid in Antibacterial Agents[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(16):2158-2164. |
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| 摘要: |
| 透明质酸是一种广泛分布于人体各组织器官中的黏多糖,是细胞外基质的主要成分之一。因其具有良好的生物相容性、抗黏附以及结构易修饰等特点,目前透明质酸已被公认为是生物医学领域中新生物材料开发的重要基石。本文对基于透明质酸设计的新型抗菌制剂及其应用进行综述,探讨透明质酸在抗菌制剂中的作用,指出透明质酸在抗菌制剂中应用的局限性与挑战性,并提出展望。 |
| 关键词: 透明质酸 抗菌制剂 靶向性 药物载体 药物缓释 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.16.019 |
| 分类号:R961 |
| 基金项目:常州市第十三批科技计划(应用基础研究)项目(CJ20210093);常州市卫生健康委重大科技项目(ZD201911) |
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| Application Progress of Hyaluronic Acid in Antibacterial Agents |
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FANG Hufeng, XU Shan, GONG Jinhong, TANG Lidan, QIAN Xiaodan, SU Dan
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Department of Pharmacy, Changzhou Second People's Hospital Affiliated to Nanjing Medical University, Changzhou 213100, China
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| Abstract: |
| Hyaluronic acid is a linear polysaccharide that is ubiquitous in the human tissues and organs.Furthermore,it is one of the primary components of the extracellular matrix.More recently,hyaluronic acid has become recognized as an important building block for the creation of new biomaterials with utility in biomedical field due to its excellent biocompatibility,anti-adhesion properties,and easy modification of the structure characteristics.This review focuses on recent advances in hyaluronic acid-based antibacterial agents and its medical application,and discusses the roles of hyaluronic acid played in antibacterial agents.The limitations and challenges in the application hyaluronic acid-based antibacterial agents are also pointed out.Finally,some prospects about hyaluronic acid used in antibacterial medicine in the future is proposed. |
| Key words: hyaluronic acid antibacterial agents targeting drug carrier drug sustained releasing |
