连接蛋白、Pannexin1：急性肝损伤治疗的新靶点

Connexin, Pannexin1: A novel therapeutic target for acute liver injury

关键词:  连接蛋白  Pannexin1  急性肝损伤  缝隙连接细胞间通信  连接蛋白通道抑制剂

Key words:  Connexin  Pannexin1  acute liver injury  gap junction intercellular communication  gap junction channel inhibitors

摘要:

缝隙连接细胞间通信(gap junction intercellular communication，GJIC)在维持肝脏内环境的稳态以及肝脏功能方面起着重要的作用，缝隙连接功能障碍会引起细胞分化异常、细胞死亡、炎症、纤维化、肝硬化以及肝癌等。近年来，越来越多证据表明，急性肝损伤存在连接蛋白、Pannexin1(Panx1)表达的改变，细胞间通信功能的障碍。本文综述急性肝损伤连接蛋白、Panx1及其缝隙连接的研究进展以及基于连接蛋白、Panx1组成的细胞通道抑制剂的研究进展，以期为寻找与缝隙连接相关蛋白为靶点的潜在治疗药物提供参考。

Abstract:

Gap junction intercellular communication(GJIC) plays an important role in maintaining the homeostasis of the liver and liver function. The dysfunction of gap junction can cause abnormal cell differentiation, cell death, inflammation, fibrosis, liver cirrhosis and liver cancer. In recent years, more and more evidences have shown that the expression of Connexins and Pannexin1(Panx1) are changed and disorders of intercellular communication in acute liver injury. Based on Connexin, Panx1, gap junction, and channel inhibitors were summaried in this paper, which may provide new perspectives and potential therapeutic agents for the treatment of actue liver injury.