| 引用本文: | 王香君,夏小雯,马明钰,任亚爽,宋现良,乔明琦,宋春红.基于抑郁症病理机制探讨芦丁抗抑郁作用[J].中国现代应用药学,2022,39(14):1895-1900. |
| WANG Xiangjun,XIA Xiaowen,MA Mingyu,REN Yashuang,SONG Xianliang,QIAO Mingqi,SONG Chunhong.Study on Antidepressant Effect of Rutin Based on Pathological Mechanism of Depression[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(14):1895-1900. |
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| 基于抑郁症病理机制探讨芦丁抗抑郁作用 |
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王香君1,2, 夏小雯3, 马明钰1,2, 任亚爽1,2, 宋现良1,2, 乔明琦2, 宋春红3
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1.山东中医药大学药学院, 济南 250355;2.山东中医药大学情志病证研究创新团队, 济南 250355;3.山东第一医科大学附属中心医院, 济南 250013
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| 摘要: |
| 芦丁是一种广泛存在于芸香、槐角、红旱莲等植物中的黄酮醇苷类成分，具有抗氧化、抗菌、抗炎、保护心脑血管等药理作用。目前研究已证明，芦丁可通过血脑屏障，作用于大脑改善认知障碍，对氧化应激、脑缺血所致的神经损伤发挥保护作用。抑郁症是一类精神障碍类疾病，主要症状为情绪低落、思维迟缓、认知功能受损等，严重影响着人类健康和生命安全。通过查阅中国知网、 PubMed 等数据库，本文将基于抑郁症的病理机制，从芦丁调控单胺类神经递质与脑源性神经营养因子水平，改善下丘脑-垂体-肾上腺轴功能，影响谷氨酸能、 GABA 能、胆碱能系统与肠道微生物群、炎症等方面进行文献梳理，探讨其潜在抗抑郁作用的研究进展，为深入研究芦丁治疗抑郁症提供思路与理论基础。 |
| 关键词: 芦丁 抑郁症 病理机制 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.14.017 |
| 分类号:R285.5 |
| 基金项目:“重大新药创制”国家科技重大专项(2017ZX09301064)；山东省自然科学基金面上项目(ZR2020MH341)；山东省中医药科技项目(2021M121)；济南市“高校20条”资助项目(2020GXRC002) |
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| Study on Antidepressant Effect of Rutin Based on Pathological Mechanism of Depression |
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WANG Xiangjun1,2, XIA Xiaowen3, MA Mingyu1,2, REN Yashuang1,2, SONG Xianliang1,2, QIAO Mingqi2, SONG Chunhong3
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1.Shandong University of Traditional Chinese Medicine, School of Pharmacy, Jinan 250355, China;2.Shandong University of Traditional Chinese Medicine, Research and Innovation Team of Emotional Diseases and Syndrome, Jinan 250355, China;3.Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China
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| Abstract: |
| Rutin is a flavonol glycoside widely found in plants such as ruta, Sophora japonica, and red dry lotus. It has antioxidant, antibacterial, anti-inflammatory, cardio-cerebrovascular protection and other pharmacological effects. At present, studies have proved that rutin can act on the brain through the blood-brain barrier, improve cognitive impairment, and play a protective role against nerve injury caused by oxidative stress and cerebral ischemia. Depression is a kind of mental disorder. Its main symptoms are depression, slow thinking and impaired cognitive function, which seriously affect human health and life safety. By consulting databases such as CNKI and PubMed, based on the pathological mechanism of depression, this paper combs the literature from the aspects of rutin regulating the levels of monoamine neurotransmitters and brain-derived neurotrophic factors, improving the function of hypothalamic pituitary adrenal axis, affecting glutamatergic, GABAergic, cholinergic system and intestinal microbiota, inflammation and so on, explores the research progress of potential antidepressant effect of rutin, provides ideas and theoretical basis for in-depth study of rutin in the treatment of depression. |
| Key words: rutin depression pathological mechanism research progress |
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