| 引用本文: | 王晓虎,刘言浩,沈朝壮,梁大虎,谢海棠,孙华.均匀设计法结合药效学优化真武汤组方配伍[J].中国现代应用药学,2023,40(3):315-320. |
| WANG Xiaohu,LIU Yanhao,SHEN Chaozhuang,LIANG Dahu,XIE Haitang,SUN Hua.Uniform Design Combined with Pharmacodynamics to Optimize the Prescription Compatibility of Zhenwu Decoction[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(3):315-320. |
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| 均匀设计法结合药效学优化真武汤组方配伍 |
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王晓虎1,2, 刘言浩3, 沈朝壮1,2, 梁大虎4, 谢海棠1, 孙华1
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1.皖南医学院弋矶山医院临床药学部/安徽省药物临床评价中心, 安徽 芜湖 241000;2.皖南医学院研究生学院, 安徽 芜湖 241002;3.蚌埠医学院第一附属医院药物临床试验机构, 安徽 蚌埠 233030;4.复旦大学药学院, 上海 201203
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| 摘要: |
| 目的 优化真武汤治疗慢性心力衰竭的组方配伍。方法 采用均匀设计对真武汤进行4因素6水平的实验设计，以6种生物碱含量为指标，进行含量测定。分别以正常大鼠、慢性心衰大鼠为模型，进行药动学、药效学实验验证。结果 真武汤按照附子:茯苓:白芍:生姜:白术为15:45:9:9:45组方时，在大鼠体内具有最佳效果，Cmax、AUC0-∞、脑钠肽等指标均优于古方(P<0.05)。结论 该组方配比疗效优于古方，可为真武汤临床应用提供一定的参考。 |
| 关键词: 真武汤 慢性心力衰竭 均匀设计法 组方配伍 |
| DOI：10.13748/j.cnki.issn1007-7693.2023.03.004 |
| 分类号:R943 |
| 基金项目:皖南医学院弋矶山医院科技创新团队“攀峰”培育计划项目(KPF2019016)；蚌埠医学院科技项目(2021byzd135) |
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| Uniform Design Combined with Pharmacodynamics to Optimize the Prescription Compatibility of Zhenwu Decoction |
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WANG Xiaohu1,2, LIU Yanhao3, SHEN Chaozhuang1,2, LIANG Dahu4, XIE Haitang1, SUN Hua1
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1.Department of Clinical Pharmacy, Yijishan Hospital of Wannan Medical College/Anhui Provincial Drugs Clinical Evaluation Center, Wuhu 241000, China;2.Graduate School of Wannan Medical College, Wuhu 241002, China;3.Drug Clinical Trial Institution, First Affiliated Hospital of Bengbu Medical College, Bengbu 233030, China;4.College of Pharmacy, Fudan University, Shanghai 201203, China
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| Abstract: |
| OBJECTIVE To optimize the prescription compatibility of Zhenwu decoction in the treatment of chronic heart failure. METHODS The experimental design of 4 factors and 6 levels was carried out on the Zhenwu decoction by uniform design, and the content of six alkaloids was used as the index to determine the content. Pharmacokinetics and pharmacodynamics were verified by using normal rats and chronic heart failure rats as models respectively. RESULTS Zhenwu decoction had the best effect in rats when the ratio of Aconiti Lateralis Radix Praeparata:Poria:Zingibers Rhizoma Recens:Paeoniae Radix Alba: Atractylodis Macrocephalae Rhizoma was 15:45:9:9:45, Cmax, AUC0-∞and brain natriuretic peptide were better than the original prescription(P<0.05). CONCLUSION The compatibility effect of this prescription is better than the original prescription, which can provide a certain reference for the clinical application of Zhenwu decoction. |
| Key words: Zhenwu decoction chronic heart failure uniform design prescription compatibility |
