| 引用本文: | 许乔,张华清,周建平,丁杨.经鼻纳米递药系统在中枢神经系统疾病治疗中的研究进展[J].中国现代应用药学,2022,39(8):1099-1104. |
| XU Qiao,ZHANG Huaqing,ZHOU Jianping,DING Yang.Advances in Intranasal Nanoscale Drug Delivery Systems for Central Nervous System Disease Therapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(8):1099-1104. |
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| 摘要: |
| 中枢神经系统疾病治疗药物的脑内递送通常受限于血脑屏障。经鼻给药作为脑靶向递药的一种无创给药方式，可绕开血脑屏障，实现药物至脑部的直接、高效靶向输送，在中枢神经系统疾病治疗中具有极大应用潜力。然而，鼻腔黏液纤毛清除力等屏障限制了经鼻给药递送效果。依托纳米递药技术的发展，经鼻纳米递药系统为中枢神经系统疾病的治疗带来了新的希望。本文综述了经鼻入脑递药通路、常见经鼻纳米递药系统及其特性和治疗应用进展，为基于中枢神经系统疾病治疗的经鼻纳米递药系统设计提供思路和方法。 |
| 关键词: 中枢神经系统疾病治疗 经鼻递送 鼻-脑通路 纳米递药系统 血脑屏障 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.08.015 |
| 分类号:R943 |
| 基金项目:国家自然科学基金项目(82073795)；省部共建药用植物功效与利用国家重点实验室开放课题基金([2022]387) |
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| Advances in Intranasal Nanoscale Drug Delivery Systems for Central Nervous System Disease Therapy |
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XU Qiao1,2, ZHANG Huaqing1,2, ZHOU Jianping1,2, DING Yang1,2
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1.Department of Pharmaceutics &2.State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China
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| Abstract: |
| Intracerebral delivery of drugs for central nervous system disease therapy is usually limited by the blood-brain barrier. As a non-invasive way of brain-targeted drug delivery, transnasal administration can bypass the blood-brain barrier to achieve direct and efficient drug delivery to the brain, which shares great applicable potential in the treatment of central nervous system disease. However, barriers like nasal cilia clearance limit intranasal drug delivery. Derived from the development of nanoscale drug delivery technology, the intranasal nanoscale drug delivery system has brought new hope for the treatment of central nervous system disease. To provide an insight into developing intranasal nanoscale drug delivery system for central nervous system disease therapy, this review summarizes the nose-to-brain pathways, characteristics and application progress of common intranasal nanoscale drug delivery systems. |
| Key words: central nervous system disease therapy intranasal delivery nose-to-brain pathway nanoscale drug delivery system blood-brain barrier |
