| 引用本文: | 郑成,赵维良,宋剑锋,汪丽霞,张文婷.衢枳壳作为枳壳药用的论证和研究[J].中国现代应用药学,2022,39(16):2096-2102. |
| ZHENG Cheng,ZHAO Weiliang,SONG Jianfeng,WANG Lixia,ZHANG Wenting.Demonstration and study of Qu Aurantii Fructus Medicinally Used as Aurantii Fructus[J].Chin J Mod Appl Pharm(中国现代应用药学),2022,39(16):2096-2102. |
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| 衢枳壳作为枳壳药用的论证和研究 |
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郑成1, 赵维良1,2, 宋剑锋3, 汪丽霞4, 张文婷1
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1.浙江省食品药品检验研究院, 国家药品监督管理局中成药质量评价重点实验室, 杭州 310052;2.杭州师范大学, 杭州 311121;3.衢州市食品药品检验研究院, 浙江 衢州 324002;4.常山县农业特色产业发展中心, 浙江 衢州 324000
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| 摘要: |
| 目的 证实衢枳壳作为枳壳药用的合理性和科学性,以恢复其作为枳壳药用的合法地位提供支持。方法 对衢枳壳作为枳壳药用的历史进行考证,通过形态、抗寒基因特性和基因测序等实验研究和文献著作考证,对其植物基原进行溯源研究,对化学成分进行文献考证和实验研究,并对药效学进行研究,对衢枳壳的质量和中国药典2020年版品种枳壳进行比较研究。结果 衢枳壳作为枳壳药用历史长达三百年左右,其植物基原为常山柚橙Citrus aurantium 'Changshan-huyou',化学成分与酸橙Citrus aurantium Linn.极为相似,药效与中国药典2020年版品种枳壳一致,其各项检验指标均符合中国药典2020年版的要求,平均合格率较药典枳壳品种更高。结论 应恢复衢枳壳作为枳壳使用的合法地位,常山柚橙应作为中国药典枳壳的基原之一。 |
| 关键词: 衢枳壳 常山柚橙 常山胡柚 枳壳 |
| DOI：10.13748/j.cnki.issn1007-7693.2022.16.008 |
| 分类号:R282.7 |
| 基金项目:浙江省药品监督管理局科技计划项目(2021001) |
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| Demonstration and study of Qu Aurantii Fructus Medicinally Used as Aurantii Fructus |
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ZHENG Cheng1, ZHAO Weiliang1,2, SONG Jianfeng3, WANG Lixia4, ZHANG Wenting1
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1.Zhejiang Institute for Food and Drug Control, NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine, Hangzhou 310052, China;2.Hangzhou Normal University, Hangzhou 311121, China;3.Quzhou Institute for Food and Drug Control, Quzhou 324002, China;4.Changshan Characteristic Industry Development Center, Quzhou 324000, China
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| Abstract: |
| OBJECTIVE To confirm the reasonableness and scientificity of Qu Aurantii Fructus medicinally used as Aurantii Fructus,so as to restore its legal status as Aurantii Fructus.METHODS A textual research on the history of Qu Aurantii Fructus as the medicinal use of Aurantii Fructus was carried out.Through experimental study and literature research for morphological characteristics,cold resistance gene and gene sequencing were carried out to confirm the plant origin.The traceability of its plant base was studied.The chemical constituents were studied in literature and experiment,and the pharmacodynamics was studied.The quality of Qu Fructus Aurantii and the Aurantii Fructus of Chinese Pharmacopoeia 2020 edition were compared.RESULTS Qu Aurantii Fructus had a medicinal history about 300 years.Its plant source was Citrus aurantium'Changshan-huyou',and its chemical composition was similar to that of Citrus aurantium Linn.The medicinal efficacy of Qu Aurantii Fructus was consistent with that of Aurantii Fructus in Chinese Pharmacopoeia 2020 Edition,and its quality indicators met the requirements of Chinese Pharmacopoeia 2020 Edition,the average qualified rate was higher than that of Aurantii Fructus in Chinese Pharmacopoeia 2020 Edition.CONCLUSION The legal status of Qu Aurantii Fructus medicinally used as aurantii Fructus should be restored,Citrus aurantium'Changshan-huyou'should be used as one of the original plans of aurantii Fructus in Chinese Pharmacopoeia. |
| Key words: Qu Aurantii Fructus Citrus aurantium'Changshan-huyou' Changshan-huyou Aurantii Fructus |
