澳洲茄边碱的抗肿瘤活性研究进展

杨丽杰; 张春梅; 赵鹤; 李宛泽; 王奇; 杨一鸣; 费瑞<sup>*</sup>

引用本文:	杨丽杰,张春梅,赵鹤,李宛泽,王奇,杨一鸣,费瑞.澳洲茄边碱的抗肿瘤活性研究进展[J].中国现代应用药学,2023,40(5):705-711.
	YANG Lijie,ZHANG Chunmei,ZHAO He,LI Wanze,WANG Qi,YANG Yiming,Fei Rui.Research Progress on Anticancer Activity of Solamargine[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(5):705-711.

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澳洲茄边碱的抗肿瘤活性研究进展
杨丽杰¹, 张春梅¹, 赵鹤¹, 李宛泽¹, 王奇^1,2, 杨一鸣¹, 费瑞^1,2
1.吉林大学基础医学院细胞生物学系, 长春 130021;2.吉林省淋巴外科重点实验室, 长春 130033

摘要:

澳洲茄边碱是从茄科植物中分离出来的，对多种肿瘤细胞均有显著抑制作用的小分子类固醇生物碱。由于其作用效果显著且具备绿色天然和不良反应低的特点，在结构上也具有明显优势，因而在临床各类癌症治疗方面有着巨大的应用价值和前景。本文对澳洲茄边碱在抗肿瘤中的应用进行了全面总结，期望为后续该产物的相关研究和进一步应用提供更多资料。

关键词: 甾体生物碱澳洲茄边碱生物活性抗肿瘤

DOI：10.13748/j.cnki.issn1007-7693.20221561

分类号:R285

基金项目:吉林省自然科学基金项目(20180101112JC)

Research Progress on Anticancer Activity of Solamargine

YANG Lijie¹, ZHANG Chunmei¹, ZHAO He¹, LI Wanze¹, WANG Qi^1,2, YANG Yiming¹, Fei Rui^1,2

1.Department of Cell Biology, College of Basic Medical Sciences, Jilin University, Changchun 130021, China;2.Jilin Provincial Key Laboratory of Lymphatic Surgery, Changchun 130033, China

Abstract:

Solamargine is a small steroid alkaloid isolated from solanaceae, which has significant inhibitory effect on a variety of cancer cells. Due to its remarkable effect, natural characteristics and low side effects, and obvious advantages in structure, it has great application value and prospect in clinical treatment of various types of cancer. In this review, the application of solamargine in cancer field was summarized comprehensively, in order to provide more information for the subsequent research and further application of solamargine.

Key words: steroid alkaloid solamargine biological activity anticancer