| 引用本文: | 孟颖月,韩轩茂,蔺雪峰.纳米氧化铈抗蒽环类药物心肌损伤作用机制研究进展[J].中国现代应用药学,2023,40(15):2161-2166. |
| MENG Yingyue,HAN Xuanmao,LIN Xuefeng.Research Progress on the Mechanism of Cerium Oxide Nanoparticles Against Anthracyclines Myocardial Injury[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(15):2161-2166. |
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| 摘要: |
| 蒽环类药物产生的剂量依赖性心脏毒性限制了其在肿瘤治疗中的深入应用。最新的动物实验研究表明，纳米氧化铈协同蒽环类药物可以提高其化疗疗效而不增加心脏正常细胞的损伤。本文通过对纳米氧化铈的生物医学性能和蒽环类药物心脏毒性的相关机制进行介绍，就纳米氧化铈在蒽环类药物心脏毒性中的抗氧化应激和抗细胞凋亡作用进行综述，为临床上防治蒽环类药物心脏毒性提供一种可能的策略。 |
| 关键词: 蒽环类药物 心肌损伤 纳米氧化铈 |
| DOI：10.13748/j.cnki.issn1007-7693.20223397 |
| 分类号:R966 |
| 基金项目:内蒙古自治区自然科学基金项目(2020MS08068，2023MS08040) |
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| Research Progress on the Mechanism of Cerium Oxide Nanoparticles Against Anthracyclines Myocardial Injury |
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MENG Yingyue1, HAN Xuanmao2, LIN Xuefeng2
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1.Graduate School, Baotou Medical College, Baotou 014040, China;2.First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China
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| Abstract: |
| Dose-dependent cardiotoxicity of anthracyclines limits its further use in cancer therapy. Recent animal studies have shown that cerium oxide nanoparticles in conjunction with anthracyclines can improve the efficacy of chemotherapy without increasing the damage to normal heart cells. This article introduces the biomedical properties of cerium oxide nanoparticles and the related mechanisms of cardiotoxicity of anthracyclines, and reviews the anti-oxidative stress and anti-apoptosis effects of cerium oxide nanoparticles in the cardiotoxicity of anthracyclines, so as to provide a possible strategy for clinical prevention and treatment of anthracyclines cardiotoxicity. |
| Key words: anthracyclines myocardial damage cerium oxide nanoparticles |
