基于动态共价键的多糖水凝胶在药物递送及组织修复中的应用研究进展

叶凡; 李思宇; 张运; 党云洁<sup>*</sup>; 杜青<sup>*</sup>

引用本文:	叶凡,李思宇,张运,党云洁,杜青.基于动态共价键的多糖水凝胶在药物递送及组织修复中的应用研究进展[J].中国现代应用药学,2023,40(21):3047-3052.
	YE Fan,LI Siyu,ZHANG Yun,DANG Yunjie,DU Qing.Research progress of Application of polysaccharide hydrogel based on dynamic covalent bond in drug delivery and tissue repair[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(21):3047-3052.

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基于动态共价键的多糖水凝胶在药物递送及组织修复中的应用研究进展
叶凡¹, 李思宇¹, 张运², 党云洁¹, 杜青¹
1.河北医科大学药学院药剂学教研室, 石家庄 050017;2.中国医学科学院药用植物研究所, 北京 100193

摘要:

水凝胶具有良好的生物相容性和生物降解性，广泛应用于药物递送、伤口敷料和组织工程等生物医学领域。按照材料来源可分为合成材料水凝胶和天然材料水凝胶，其中天然多糖水凝胶不仅可以作为材料应用，还具有独特的药理活性和较好的机械性能，逐渐成为首选材料。动态共价键水凝胶由于其结构灵活性、自愈合性能和环境响应性备受关注。本文对采用动态键方式的天然多糖水凝胶体系进行归类和总结，并对该类水凝胶在药物递送以及组织修复方面的研究现状进行概述，以期为新型多糖水凝胶的临床应用提供借鉴。

关键词: 水凝胶多糖动态共价键药物递送

DOI：10.13748/j.cnki.issn1007-7693.20223433

分类号:R941

基金项目:河北省教育厅引进留学人才项目(C20220345)；河北省自然科学基金生物医药联合基金培育项目(H20202066)

Research progress of Application of polysaccharide hydrogel based on dynamic covalent bond in drug delivery and tissue repair

YE Fan¹, LI Siyu¹, ZHANG Yun², DANG Yunjie¹, DU Qing¹

1.Department of Pharmaceutics, School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China;2.Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China

Abstract:

Hydrogels are widely used in biomedical fields such as drug delivery, wound dressings and tissue engineering because of their good biocompatibility and biodegradability. According to the source of material, it can be divided into synthetic material hydrogel and natural material hydrogel. Natural polysaccharide hydrogel not only can be used as material, but also has unique pharmacological activity and better mechanical properties, gradually become the preferred material. Dynamic covalent hydrogels have attracted much attention due to their structural flexibility, self healing performance and environmental responsiveness. In this paper, the dynamic bond mode natural polysaccharide hydrogel systems are classified and summarized, and the research status of the construction of this kind of hydrogel in drug delivery and tissue repair are summarized, to provide reference for the application of new polysaccharide hydrogels in clinical application.

Key words: hydrogel polysaccharide dynamic bond drug delivery