| 引用本文: | 王相龙,邱利焱.壳聚糖递送系统在肿瘤光热治疗中的应用和进展[J].中国现代应用药学,2023,40(12):1728-1737. |
| WANG Xianglong,QIU Liyan.Application and Development of Chitosan-based Delivery Systems in Tumor Photothermal Therapy[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(12):1728-1737. |
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| 摘要: |
| 肿瘤持续侵袭着人类健康，光热治疗作为一种肿瘤治疗的新方法受到越来越多的关注和研究。壳聚糖是一种天然来源丰富的阳离子多糖，具有良好的生物相容性、可降解性、结构衍生化特性。壳聚糖及其衍生物的骨架上含有大量的氨基和羟基，可通过物理或者化学方法形成壳聚糖纳米粒、水凝胶以及涂层等多种形式的载体，装载或结合光热转换剂，在近红外激光辐射下形成局部高温抑制肿瘤细胞。本综述系统介绍了壳聚糖递送系统在肿瘤光热治疗方面的研究进展。 |
| 关键词: 壳聚糖 肿瘤光热治疗 纳米粒 水凝胶 材料涂层 |
| DOI：10.13748/j.cnki.issn1007-7693.20230340 |
| 分类号: |
| 基金项目:国家自然科学基金项目(82073781) |
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| Application and Development of Chitosan-based Delivery Systems in Tumor Photothermal Therapy |
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WANG Xianglong, QIU Liyan
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Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Tumor continues to invade human health. As a new method of tumor treatment, photothermal therapy has received more and more attention. Chitosan is a kind of cationic polysaccharide with rich natural sources, which has good biocompatibility, degradability and structural derivatization characteristics. Since the skeleton of chitosan and its derivatives contains a large number of amino and hydroxyl groups, chitosan and its derivatives can act as carriers in form of nanoparticles, hydrogels, coatings and others by physical or chemical methods to load photothermal conversion agents and facilitate their effect of killing tumor cells under near-infrared laser radiation. This review systematically introduces the research progress of chitosan-based delivery systems in tumor photothermal therapy. |
| Key words: chitosan tumor photothermal therapy nanoparticles hydrogel material coating |
