药师主导干预改善哮喘儿童长期使用布地奈德依从性的随机对照试验

Pharmacist-led Intervention to Improve Compliance to Long-term Use of Budesonide in Asthma Children: A Randomized Controlled Trial

关键词:  依从性  随机对照  哮喘  布地奈德

Key words:  compliance  randomized controlled  asthma  budesonide

摘要:

目的 通过临床药师主导的多学科精准用药护理，评估绍兴地区儿童哮喘患者长期服用布地奈德临床治疗结果及用药依从性的关系和影响。方法 采用随机对照试验设计，以绍兴市妇幼保健院2022年1月1日—2022年12月1日收治的儿童哮喘患者为研究对象，根据纳入与排除标准，选取106例患者入组，随机等分为干预组(药师主导的多学科精准护理组)和对照组(常规护理组)。对比2组在肺功能，Morisky儿童用药依从性量表，IgE、嗜酸性粒细胞计数、药物信息满意度量表及服药信念量表上的区别。结果 干预组的肺功能水平、Morisky评分、IgE、嗜酸性粒细胞计数及用药依从性均显著优于对照组，且差异具有统计学意义。结论 临床药师主导的多学科护理团队显著改善哮喘患儿的临床结果和用药依从性。

Abstract:

OBJECTIVE To evaluate the relationship and impact of long-term budesonide treatment results and medication compliance of children with asthma in Shaoxing through multidisciplinary precision medication nursing led by clinical pharmacists. METHODS Randomized controlled trial design was adopted. Children with asthma admitted to Shaoxing Maternity and Child Health Care Hospital from January 1, 2022 to December 1, 2022 were taken as the research objects. According to the inclusion and exclusion criteria, 106 patients were selected to be included in the group, and randomly divided into intervention group(multidisciplinary precision care group led by pharmacists) and control group(conventional care group). Compared the differences of lung function, Morisky Children’s Medication Compliance Scale, IgE, eosinophil count, drug information satisfaction scale and medication belief scale between the two groups. RESULTS The lung function level, Morisky score, lgE, eosinophil count and medication compliance of the intervention group were significantly better than those of the control group, and the differences had statistical significance. CONCLUSION A multidisciplinary nursing team led by clinical pharmacists has significantly improved the clinical outcomes and medication compliance of children with asthma.