IL-13介导的信号网络参与变应性鼻炎黏液高分泌及中药干预作用的研究现状

Research progress of IL-13-mediated signaling pathways participating in allergic rhinitis mucus hypersecretion and the intervention effect of traditional Chinese medicine

关键词:  变应性鼻炎  黏液高分泌  白介素-13  信号网络  中药  研究现状

Key words:  allergic rhinitis (AR)  mucus hypersecretion  interleukin-13 (IL-13)  signaling pathway  traditional Chinese medicine  research progress

摘要:

变应性鼻炎(AR)是一种鼻黏膜变应性炎症性疾病,免疫炎症反应改变了鼻黏膜局部微环境,引起的黏液高分泌是AR的主要病理学特征之一。白介素-13(IL-13)是Th2细胞分泌的主要炎性因子,可通过多种信号网络调控杯状细胞(GC)增生及黏蛋白5ac(Muc5ac)表达而参与AR黏液高分泌过程。中医药在治疗AR及其黏液高分泌方面有明显的优势,而通过IL-13介导的信号网络是其治疗AR黏液高分泌的重要作用机制之一。本文就IL-13介导信号网络调控AR黏液高分泌以及中药干预作用进行综述,为AR黏液高分泌的实验研究与新药研发提供理论依据。

Abstract:

Allergic rhinitis (AR) is an allergic inflammatory disease of the nasal mucosa in which the immune inflammatory response alters the local microenvironment of the nasal mucosa, causing mucus hypersecretion as one of the main pathological features of AR.Interleukin-13 (IL-13) is the main inflammatory factor secreted by Th2 cells, it can be involved in AR mucus hypersecretion process by regulating Goblet cell (GC) proliferation and Mucin 5ac (Muc5ac) expression through various signaling pathways.Chinese medicine has obvious advantages in the treatment of AR and its mucus hypersecretion, while the IL-13-mediated signaling pathways are one of the important mechanisms in treating AR mucus hypersecretion.This article reviews the regulation of IL-13-mediated signaling pathways on AR mucus hypersecretion and the intervention effects of traditional Chinese medicine, which providing a theoretical basis for experimental research and new drug development in AR mucus hypersecretion.