| 引用本文: | 朱秀萍,徐亚萍,陆扬,董晓武,鲁兖.铁死亡及其抑制剂研究进展[J].中国现代应用药学,2025,42(11):160-171. |
| zhu xiuping,xu yaping,lu yang,dong xiaowu,lu yan.Research Progress of Ferroptosis and the Inhibitors[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(11):160-171. |
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| 摘要: |
| 铁死亡是一种新型的程序性细胞死亡形式,受铁、氨基酸、多不饱和脂肪酸等多种代谢方式调节,已被证明参与肿瘤、缺血再灌注损伤、神经退行性疾病等多种疾病的病理过程。目前已发现多种具有不同作用机制的铁死亡抑制剂,在多种疾病模型中表现出良好的治疗效果。本文对近年来的铁死亡抑制剂进行综述,为其进一步研究提供思路。 |
| 关键词: 铁死亡 抑制剂 ferrostatin-1 liproxstatin-1 |
| DOI：10.13748/j.cnki.issn1007-7693.20232168 |
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| Research Progress of Ferroptosis and the Inhibitors |
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zhu xiuping1, xu yaping2, lu yang3, dong xiaowu1,3, lu yan1
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1.The Second Affiliated Hospital,Zhejiang University School of Medicine;2.Institute of Drug Discovery and Design, College of Pharmaceutical Sciences;3.Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou
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| Abstract: |
| Ferroptosis is a new form of non-apoptotic cell death, regulated by multiple cellular metabolic pathways such as iron handling as well as metabolism of amino acids and lipids. Since its identification in 2012, mounting studies have shown that ferroptosis is involved in various diseases including cancers, ischemia-reperfusion injury and degenerative pathologies. Up to now, numerous ferroptosis inhibitors targeting various signaling pathways relevant to the above diseases have been discovered. In this review, current knowledge on the modulation of ferroptosis was elaborated, followed by summarizing recent ferroptosis inhibitors together with their pharmacological activities, in an attempt to boost a perspective for future study. |
| Key words: ferroptosis inhibitors ferrostatin-1 liproxstatin-1 |
