| 引用本文: | 解鑫赫,刘润红,侯月秀,赵瑞玲.头孢唑林与头孢呋辛用于儿童清洁手术预防用药的临床综合评价[J].中国现代应用药学,2023,40(22):3129-3135. |
| XIE Xinhe,LIU Runhong,HOU Yuexiu,ZHAO Ruiling.Clinical Comprehensive Evaluation of Cefazolin and Cefuroxime in Pediatric Clean Surgical Prophylaxis[J].Chin J Mod Appl Pharm(中国现代应用药学),2023,40(22):3129-3135. |
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| 摘要: |
| 目的 开展儿童清洁手术(I类切口)预防用药的临床综合评价，促进围术期预防用抗菌药物的合理使用。方法 根据《药品临床综合评价管理指南(2021年版试行)》，应用文献研究法、头脑风暴、专家访谈法、德尔菲法构建清洁手术(I类切口)预防用药的临床综合评价体系；收集评价证据并开展多维度、多层次证据的综合评判。结果 临床综合评价体系包括5个1级指标(安全性、有效性、经济性、适宜性和可及性)，11个2级指标，30个3级指标；头孢唑林临床综合评价得分86.09，头孢呋辛评分为82.45分，前者在安全性、有效性、经济性、适宜性4个方面优于后者，后者可及性优于前者。结论 本研究所构建的儿童清洁手术(I类切口)预防用药临床综合评价体系有较高的科学性，评价结果可为医疗机构清洁手术(I类切口)抗菌药物的遴选提供依据。 |
| 关键词: 头孢唑林 头孢呋辛 儿童 清洁手术 临床综合评价 |
| DOI：10.13748/j.cnki.issn1007-7693.20232566 |
| 分类号:R969.3 |
| 基金项目: |
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| Clinical Comprehensive Evaluation of Cefazolin and Cefuroxime in Pediatric Clean Surgical Prophylaxis |
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XIE Xinhe1, LIU Runhong2, HOU Yuexiu3, ZHAO Ruiling3,4
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1.Department of Pharmacy, General Hospital of Taiyuan Iron & Steel(Group) Go., Ltd., Taiyuan 030008, China;2.Department of Pharmacy, The Yangpu East Hospital of Shanghai, Shanghai 200438, China;3.College of Pharmacy, Shanxi Medical University, Taiyuan 030001, China;4.Office of Drug Trial Institution, Shanxi Children's Hospital, Taiyuan 030013, China
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| Abstract: |
| OBJECTIVE To carry out clinical comprehensive evaluation of prophylactic drugs for clean surgery(type I incision) in children, and to promote the rational use of antibiotics during perioperative period. METHODS According to the Guidelines for the Management of Comprehensive Clinical Evaluation of Drugs(trial edition of 2021), the clinical comprehensive evaluation system of prophylactic drugs for clean surgery(type I incision) was established by using the methods of literature research, brainstorming, expert interview and Delphi, and the evaluation evidence was collected to carry out the comprehensive evaluation of multi-dimensional and multi-level evidence. RESULTS The clinical comprehensive evaluation system was constructed, including 5 first-class indicators(safety, effectiveness, economy, suitability, and accessibility), 11 second-class indicators and 30 third-class indicators. The clinical comprehensive evaluation score of cefazolin was 86.09, and that of cefuroxime was 81.86. The former was better than the latter in safety, effectiveness, economy and suitability, while the latter was better than the former in accessibility. CONCLUSION The clinical comprehensive evaluation of prophylactic drugs for clean surgery(type I incision) in children constructed in this study is scientific, and the results provides a basis for the selection of antibiotics for clean surgery(type I incision) in hospital. |
| Key words: cefazolin cefuroxime children clean surgery clinical comprehensive evaluation |
