| 摘要: |
| 目的：为免疫检查点抑制剂（ICIs）超说明书用药提供参考，促进ICIs临床合理用药。方法 组建多学科的专家团队，在循证证据的基础上，通过多轮专家研讨，形成ICIs超说明书用药实践指南。结果 共纳入有充分循证证据支持的超说明书用药条目212条，其中CTL-A4抑制剂20条，PD-1抑制剂179条，PD-L1抑制剂13条。结论 本指南明确了循证证据充分的ICIs超说明书用药范围，为ICIs的超说明书用药管理提供了实用的参考资料。 |
| 关键词: 免疫检查点抑制剂 ICIs 超说明书用药 |
| DOI： |
| 分类号:R284.1；R917.101?????? |
| 基金项目:浙江省医药卫生科技计划项目(2023KY521)；浙江省“万人计划”(2020R52029)；浙江省卫生高层次人才医坛新秀(浙卫办〔2022〕32号,浙卫办〔2020〕18号) |
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| Practice guidelines for off-label use of immune checkpoint inhibitors |
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zhengxiaowei
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浙江省人民医院药学部
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| Abstract: |
| ABSTRACT: OBJECTIVE To provide reference for the off-label use of immune checkpoint inhibitor (ICIs), and to promote the clinical rational use of ICIs. METHODS A multi-disciplinary expert team was set up, and the practice guidelines was formed through many rounds of expert discussion on the basis of evidence-based medicine. RESULTS A total of 212 items of off-label use supported by sufficient evidence were included, including 20 items about CTL-A4 inhibitors, 179 items about PD-1 inhibitors and 13 items about PD-L1 inhibitors.CONCLUSION This guide clarify the off-label use of ICIs with sufficient evidence, and provides a practical reference for ICIs off-label use management. |
| Key words: immune checkpoint inhibitors ICIs off-label use |
