基于组学技术探讨天然化合物在肿瘤中的研究进展

Research Progress on Natural Compounds in Tumors Based on Omics Technology

关键词:  天然化合物  恶性肿瘤  组学技术

Key words:  natural compounds  malignancy  omics technology

摘要:

恶性肿瘤是严重威胁人类健康的主要原因之一。随着各种抗肿瘤药物的研发，天然化合物对不同类型的恶性肿瘤表现出强大的作用。组学（Omics）是研究生物体中分子组分和其相互作用及作用网络的一门学科，主要包括蛋白质组学、转录组学、代谢组学、基因组学、免疫组学、影像组学等，广泛应用于天然化合物治疗肿瘤的机制研究中。单组学和多组学技术有助于揭示具有抗肿瘤潜力的天然化合物的信号相互作用网络和关键分子靶点。因此对近年来各种组学方法在检测抗肿瘤天然化合物的治疗靶点、信号通路和肿瘤微环境方面的应用进行了归纳总结，为组学技术探索天然化合物的抗肿瘤研究提供新的依据和思路。

Abstract:

Malignant tumors are one of the main causes of serious threats to human health. With the development of various anti-tumor drugs, natural compounds have shown strong effects on different types of malignant tumors. Omics is a discipline that studies the molecular components and their interactions and interaction networks in living organisms. It mainly includes proteomics, transcriptomics, metabolomics, genomics, immunology, imaging omics, etc. It is widely used in the study of the mechanisms of natural compounds in treating tumors. Monoomics and multiomics techniques can help reveal the signal interaction networks and key molecular targets of natural compounds with anti-tumor potential. Therefore, the application of various omics methods in detecting therapeutic targets, signaling pathways, and tumor microenvironment of anti-tumor natural compounds in recent years has been summarized and summarized, providing new basis and ideas for omics technology to explore the anti-tumor research of natural compounds.