| 引用本文: | 春娟,马秀娟,刘芳琳,赵蕊,周昔程.药源性假性高甘油三酯的识别和管理[J].中国现代应用药学,2024,41(19):89-94. |
| 张,maxiujuan,liufanglin,zhaorui,zhouxicheng.Drug induced Pseudo-hypertriglyceridemia: recognition and management[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(19):89-94. |
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| 摘要: |
| 目的 开发怀疑药源性假性高甘油三酯血症（Pseudo-hypertriglyceridemia，Pseudo-HTG）的临床鉴别流程，有助于临床药师协助医生进行药源性Pseudo-HTG的识别和管理；并提出药学监护途径，为临床药师的工作切入和监护提供参考。方法 描述了一例由药物中的甘油辅料导致的Pseudo-HTG的病例，并回顾迄今为止发表的药源性Pseudo-HTG文献，总结病例的临床和生化特征，确定HTG与药物的相关性。结果 饮酒史，肾功能损伤是Pseudo-HTG的高危因素，药源性Pseudo-HTG在停止外源性摄入后，TG值常可在3-5天内恢复，但伴有肾功能损伤患者若未经连续肾脏替代治疗（continuous renal replacement therapy，CRRT）治疗，恢复时间可能延长至数月。结论 药源性Pseudo-HTG的临床鉴别需要医师和药师的互相协作，含甘油药物的大量摄入、导致Pseudo-HTG药物的应用，均可能会造成药源性Pseudo-HTG。临床药师可从建立辅料数据库、跟踪前沿药学研究、患者教育和用药监护方面切入Pseudo-HTG患者的药学监护工作。 |
| 关键词: 假性高甘油三酯血症 药源性 临床药师 药学监护 |
| DOI： |
| 分类号:R97 |
| 基金项目: |
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| Drug induced Pseudo-hypertriglyceridemia: recognition and management |
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张1, maxiujuan1, liufanglin1, zhaorui2, zhouxicheng3,4,5
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1.海盐县人民医院;2.Zhejiang University School of Medicine Sir Run Run Shaw Hospital;3.haiyan people'4.'5.s hospital
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| Abstract: |
| OBJECTIVE To explore an identification flow chart of drug-inducd pseudo-hypertriglyceridemia, (Pseudo-HTG), which would help clinical pharmacists assist doctors to identify and manage drug-induced pseudo-HTG. Besides, several pharmaceutical care ways were proposed to provide reference for clinical pharmacists. METHODS A patient with Pseudo-HTG induced by glycerol excipients was introduced, and drug-induced Pseudo-HTG literatures were reviewed. The characteristics of drug induced Pseudo-HTG were summarized to determine the correlation between HTG and drugs. RESULTS The history of alcohol consumption and renal dysfunction are high-risk factors for Pseudo-HTG. TG value of drug induced Pseudo-HTG could usually recover within 3-5 days after exogenous intake discontinue. However, the recovery time of patients with renal dysfunction who do not receive continuous renal replacement therapy (CRRT) may be extended to several months. CONCLUSION The clinical identification of drug-induced Pseudo-HTG requires collaboration between physicians and pharmacists. The excessive intake of exogenous drugs with glycerol and the use of Pseudo-HTG drugs may lead to drug-induced Pseudo-HTG. Pharmaceutical care could be carried out from the following aspects, establishing excipient databases, tracking cutting-edge pharmaceutical research, patient education, and medication monitoring. |
| Key words: Pseudo-hypertriglyceridemia Drug-induced Clinical pharmacists Pharmaceutical care |
