HIV/AIDS患者剖宫产术围手术期抗菌药物使用疗程与术后感染的关系

Relationship Between the Duration of Perioperative Antibiotic Use and Postoperative Infection in HIV/AIDS Patients Undergoing Cesarean Section

关键词:  剖宫产  抗菌药物  使用疗程  感染

Key words:  cesarean section  antibiotics  course of treatment  infection

摘要:

目的 探讨人类免疫缺陷病毒/艾滋病(human immunodeficiency virus/acquired immune deficiency syndrome，HIV/AIDS)孕妇剖宫产术围手术期抗菌药物使用疗程与术后感染的关系，指导临床合理使用抗菌药物。方法 选取2014年1月—2022年9月53例HIV/AIDS剖宫术产妇为研究对象，根据抗菌药物使用疗程将产妇分为2组，研究组(n=31)抗菌药物使用疗程>24 h且≤48 h，对照组(n=22)抗菌药物使用疗程≤24 h，观察术后切口愈合情况、炎症指标、术后感染率、术后住院时间等。结果 研究组和对照组术后体温、白细胞计数、中性粒细胞比率、C-反应蛋白、术后住院时间、伤口愈合等级以及术后感染率方面均无统计学差异。结论 HIV/AIDS患者剖宫产术围手术期抗菌药物使用疗程≤24 h即可能起到较好的预防术后感染的作用。

Abstract:

OBJECTIVE To investigate the relationship between the course of antibiotics during perioperative period and postoperative infection in pregnant women with human immunodeficiency virus/acquired immune deficiency syndrome(HIV/AIDS) undergoing cesarean section, and to guide the rational use of antibiotics in clinical practice. METHODS A total of 53 cesarean section women in the hospital from January 2014 to September 2022 were chosen as research objects. According to the course of antibiotics, the puerperae were divided into two groups. The treatment course of antibiotics in the study group(n=31) was >24 h and ≤48 h, and the control group(n=22) was ≤24 h. The postoperative wound healing, inflammatory indexes, postoperative infection rate, and postoperative hospital stay were observed. RESULTS There was no significant difference in postoperative body temperature, white blood cell count, neutrophil ratio, C-reactive protein, postoperative hospital stay, wound healing grade and postoperative infection rate between the study group and the control group. CONCLUSION Antibiotics for HIV/AIDS patients during perioperative period of cesarean section for <24 h may play a better role in preventing postoperative infection.