基于“药性-成分-配伍-炮制”的淫羊藿药性药效考证

Research on drug efficacy of Epimedium based on “Propertiy - Composition - Compatibility - Processing”

关键词:  淫羊藿  性味功效  活性成分  组方配伍  炮制方法

Key words:  Epimedium  ? Sex and taste effect  ? Active ingredient  ? Combination of prescriptions  ? Processing method

摘要:

目的:为深入探讨淫羊藿性味功效的发展演变历程,整理并分析其性味功效与化学成分、组方配伍、炮制方式之间的关系,以期为淫羊藿的临床应用及进一步研究提供有益参考。方法:以中医药理论为指导,通过梳理历代本草著作中有关淫羊藿的记载,结合淫羊藿活性成分、组方配伍与炮制方法,归纳、探讨其药性和药效的发展规律,对其发生变化的原因进行逐一解释和阐明。结果:淫羊藿药用历史悠久,为临床常见中药材,其所含化学成分多为黄酮类化合物,常配伍温补类中药使用,炮制方式多为羊脂油拌炒法,药用以炙淫羊藿较多。自东汉时期的《神农本草经》至当今现行的《中国药典》,淫羊藿药性记载自“辛、寒”变为“辛、甘,温”,推测淫羊藿药性的差异变化的原因可能与其经过炮制过程有关。而古今对淫羊藿功效的认识较为统一,具有补肾壮阳,强筋健骨,祛风除湿等功效。结论:经考证理清了淫羊藿药性的发展演变过程,结合现代药理学研究成果和中药现代化,深入挖掘淫羊藿的药性药效,为探索其在临床应用中的潜力提供了极其重要的价值。

Abstract:

Objective: In order to deeply explore the development and evolution of the sexual taste effect of Epimedium, the relationship between the sexual taste effect and chemical composition, composition and preparation method was sorted out and analyzed, in order to provide useful reference for the clinical application and further research of Epimedium. Methods: Guided by the theory of traditional Chinese medicine, by combing the records of Epimedium in the works of Materia Medica, combined with the active ingredients, the compatibility and processing methods of Epimedium, the development law of its medicinal properties and effects were summarized and discussed, and the reasons for its changes were explained and clarified one by one. Result: Epimedium has a long history of medicinal use and is a common clinical Chinese medicinal material. Its chemical components are mostly flavonoids, and it is often used with warm and tonic Chinese medicine. The processing method is mostly mixed with sheep fat oil, and the medicinal use is mostly grilled Epimedium. From the Shennong Materia Medica in the Eastern Han Dynasty to the current Chinese Pharmacopoeia, the drug properties of Epimedium were recorded from "hot and cold" to "hot, sweet and warm". It was speculated that the reason for the difference in the drug properties of Epimedium might be related to the processing process. The ancient and modern understanding of the effect of Epimedium is more unified, with the effect of tonifying the kidney and strengthening the Yang, strengthening the tendon and bones, dispelling wind and dehumidifying. Conclusion: The research has clarified the development and evolution of the drug properties of Epimedium, combined with modern pharmacological research results and the modernization of Chinese medicine, and further explored the drug efficacy of Epimedium, which provides extremely important value for exploring its potential in clinical application.