丁苯酞调控NF-κB通路缓解脑血管疾病炎症反应的实验研究进展

Experimental research progress on Butylphthalide alleviating inflammatory response in cerebrovascular disease by regulating NF-κB signaling pathway

关键词:  丁苯酞  抗炎  脑血管疾病  NF-κB  研究进展  

Key words:  butylphthalide (NBP)  anti-inflammation  cerebrovascular disease  nuclear factor-κb (NF-κB)  research progress

摘要:

丁苯酞（NBP）作为一种多靶点的神经保护剂，具有抗炎、调节免疫等多种药理作用，对脑血管疾病（包括缺血性脑卒中、出血性脑卒中及血管性痴呆等）过程中的免疫炎症反应具有明显的缓解作用。核因子-κB（NF-κB）广泛参与免疫炎症反应，近年来研究发现NBP通过调控NF-κB、缓解免疫炎症反应而发挥治疗脑血管疾病的作用。文章就NBP调控NF-κB信号通路而缓解脑血管疾病免疫炎症反应的实验研究进行综述。

Abstract:

Butylphthalide (NBP) is a multi-target neuroprotective agent with diverse pharmacological effects, notably anti-inflammatory and immunomodulatory properties. It significantly alleviates the immune-inflammatory response in cerebrovascular diseases, including ischemic stroke, hemorrhagic stroke, and vascular dementia, among others. Nuclear factor-κB (NF-κB) is a pivotal factor widely involved in immune-inflammatory responses. Recent studies have revealed that NBP exerts its therapeutic effects on cerebrovascular diseases by modulating NF-κB and alleviating immune-inflammatory responses. This review summarizes experimental studies on how NBP regulates the NF-κB signaling pathway to mitigate immune-inflammatory responses in cerebrovascular diseases.