| 引用本文: | 刘碧垚,王安琪,张秀华,於怀龙,邵华荣,张岱州,刘飞.骨靶向药物研究进展[J].中国现代应用药学,2025,42(15):189-196. |
| LiuBiYao,WanQi,ZhangXiuHua,YuHuaiLong,ShaoHuaRong,ZhangDaiZhou,LiuFei.Research progress on bone targeted drug[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(15):189-196. |
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| 骨靶向药物研究进展 |
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刘碧垚1,2, 王安琪1,2, 张秀华2, 於怀龙2, 邵华荣1,2, 张岱州1,2, 刘飞1,2
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1.山东中医药大学药学院;2.山东省药学科学院，山东省生物药物重点实验室
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| 摘要: |
| 近年来,随着人口老龄化程度不断加剧,骨相关疾病的发病率和社会关注度显著增加。鉴于骨组织结构致密且血流量少,全身给药后药物进入骨组织的渗透效率相对较低,因此“骨靶向药物”的概念被提出,骨靶向药物能使药物快速到达病变骨组织发挥作用,提高药物疗效和减少不良反应的发生。目前常用双磷酸盐类化合物、四环素和天冬氨酸寡肽类化合物等制备新型骨靶向药物递送系统和骨靶向偶联药物的研究。本文查阅相关骨靶向药物的文献研究资料,综述了近年来新型骨靶向药物的设计策略、制备工艺、药效等方面的研究进展，为骨相关疾病治疗新思路和新策略研究提供参考。 |
| 关键词: 骨靶向药物 双磷酸盐 四环素 天冬氨酸寡肽 |
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| 基金项目:山东省重点研发计划资助项目(编号:2021CXGC010501)，山东省自然科学基金面上项目(编号:ZR2021MH219) |
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| Research progress on bone targeted drug |
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LiuBiYao1,2, WanQi1,2, ZhangXiuHua2, YuHuaiLong2, ShaoHuaRong1,2, ZhangDaiZhou1,2, LiuFei1,2
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1.college of pharmacy, Shandong University of Traditional Chinese Medicine;2.Shandong Academy of Pharmaceutical Sciences, Shandong Provincial Key Laboratory of Biopharmaceuticals
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| Abstract: |
| Recent demographic trends show a significant rise in both the incidence of bone-related diseases and the associated societal concern, driven by an increasingly aging population. Given the dense structure and low blood flow of bone tissue, the permeation efficiency of drugs into bone tissue after systemic administration is relatively low. As a result, the concept of "bone-targeted drugs" has emerged. Bone-targeted drugs enable drugs to quickly access to diseased bone tissue, greatly enhancing drugs therapy effects and reducing the occurrence of adverse reactions. Currently, there are numerous innovative design schemes and application strategies for bone-targeted drugs, often utilizing bisphosphonates, tetracyclines, and aspartic acid oligopeptide substances to develop new bone-targeted drug delivery systems and coupled targeted drugs. This article reviews the literature and research on bone-targeted drugs, summarizing the recent progress in design strategies, preparation processes, and pharmacological effects of new bone-targeted drugs, providing novel treatment ideas and design strategies for the management of bone related diseases. |
| Key words: bone targeted drugs diphosphate tetracycline aspartate oligopeptide |
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