刺激响应型自组装多肽递送系统用于癌症治疗的研究进展

Research progress of stimulus-responsive self-assembled peptides-based delivery system for cancer therapy

关键词:  多肽  自组装  刺激响应  递送系统  癌症治疗

Key words:  peptides  self-assembly  stimuli-responsive  delivery system  cancer therapy

摘要:

癌症发病率与死亡率居高不下，已成为威胁人类健康的首要问题。传统癌症治疗手段如放疗、化疗、免疫疗法等虽能抑制癌症进展，但伴随药物体内清除快、体内无选择性分布与治疗效果有限等问题。自组装多肽具备良好的生物相容性、生物降解性与易于修饰性，作为低毒高效的药物载体备受研究者的青睐。利用体内外响应因素开发功能多样的刺激响应型多肽递送系统，对提高药物的靶向性与增强抗癌效果优势显著。本文系统总结了刺激响应型自组装多肽的组装驱动力、响应类型、作用机制以及优势，并重点对刺激响应型自组装多肽在癌症治疗中的研究现状与临床应用进行论述与展望，以期为新型刺激响应型多肽递送系统的设计提供研究思路。

Abstract:

The escalating prevalence and fatality rates of cancer pose a significant challenge to human health. Conventional cancer therapies including radiotherapy, chemotherapy, and immunotherapy can impede cancer advancement, are hindered by issues such as rapid drug metabolism, non-specific distribution, and restricted efficacy. Self-assembled peptides, characterized by favorable biocompatibility, biodegradability, and modifiability, have garnered interest from researchers as promising drug carriers due to their low toxicity and high efficiency. The development of a variety of stimuli-responsive peptide delivery systems using in vitro and in vivo response factors has significant advantages in improving drug targeting and enhancing anticancer effects. This study comprehensively summarizes the driving forces, response type, mechanisms and advantages of stimuli-responsive self-assembled peptides, and the research status and clinical application of stimuli-responsive self-assembled peptides in cancer treatment are emphatically discussed and prospected, in order to offer research ideas for the development of innovative stimulus-responsive peptide systems.