TRPV1介导神经源性炎症介质调控变应性鼻炎的研究进展

Progress in the modulation of allergic rhinitis through TRPV1-mediated neurogenic inflammatory mediators

关键词:  变应性鼻炎  瞬时感受器电位香草酸受体1  神经肽  神经营养素  神经源性炎症

Key words:  allergic rhinitis (AR)  transient receptor potential vanilloid receptor 1 (TRPV1)  neuropeptide  neurotrophins  neurogenic inflammation

摘要:

变应性鼻炎(AR)是一种常见的鼻腔免疫炎症性疾病,鼻粘膜免疫炎症反应是其基础病理学特征。瞬时感受器电位香草酸受体1(TRPV1)是一种非选择性阳离子通道,其兴奋后可引起P物质(SP)、降钙素基因相关肽(CGRP)以及血管活性肠肽(VIP)等神经源性炎症介质的释放,共同参与调控神经源性炎症反应。近年来研究发现,TRPV1及其介导的神经源性炎症介质对AR及其病理学反应具有明显的调控作用,本文就TRPV1介导的神经源性炎症介质在AR中的研究进展进行综述,为AR的基础研究与新药研发提供理论依据。

Abstract:

Allergic rhinitis (AR) is a prevalent immune-mediated inflammatory disorder of the nasal cavity, immune-inflammatory response in the nasal mucosa as it fundamental pathological feature. Transient receptor potential vanilloid receptor 1 (TRPV1) as a non-selective cation channel, upon activation, triggers the release of neurogenic inflammatory mediators such as substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP), among others, these mediators collectively contribute to the modulation of neurogenic inflammation. Recent studies have demonstrated that TRPV1 and its associated neurogenic inflammatory mediators exert significant regulatory effects on AR and its pathological manifestations. This review aims to summarize the advancements in research regarding TRPV1-mediated neurogenic inflammatory mediators in AR, thereby providing a theoretical foundation for both basic research and novel drug development targeting AR.