基于肠道菌群探讨逍遥散治疗抑郁症的研究进展

Research Progress on Xiaoyaosan for Treating Depression: A Gut Microbiota Perspective

关键词:  抑郁症,肠道菌群,逍遥散,抗抑郁机制

Key words:  Depression, Gut  Microbiota, Xiaoyaosan, Antidepressant  Mechanism

摘要:

抑郁症的发病率逐年上升,病因尚不明确。肠道菌群在抑郁症的发生和发展中发挥重要作用,通过炎症反应、HPA轴调节、单胺类神经递质调节和神经营养因子的调节等途径参与其中。因此,调节肠道菌群已成为治疗抑郁症的新兴方向。逍遥散作为一种经典的中医药方剂,其治疗抑郁症的效果显著且优势突出。大量研究已证实,逍遥散通过调节肠道菌群发挥抗抑郁作用。本文综述了近年来关于逍遥散治疗抑郁症患者肠道菌群变化、肠道菌群在抑郁症发病机制中的作用及逍遥散调节肠道菌群抗抑郁的相关研究。通过总结这些研究,本文为抑郁症的防治和中医药的进一步开发提供参考。

Abstract:

ABSTRACT: The incidence of depression is increasing annually, with its etiology still unclear. The gut microbiota plays a significant role in the onset and development of depression, participating through pathways such as inflammatory responses, HPA axis regulation, monoamine neurotransmitter modulation, and neurotrophic factor regulation. Thus, modulating the gut microbiota has become an emerging direction for treating depression. Xiaoyaosan, a classical traditional Chinese medicine formula, has shown remarkable effectiveness in treating depression, with significant advantages. Numerous studies have confirmed that Xiaoyaosan exerts its antidepressant effects by regulating the gut microbiota. This review summarizes recent studies on the changes in gut microbiota in patients with depression treated with Xiaoyaosan, the role of gut microbiota in the pathogenesis of depression, and the antidepressant mechanisms of Xiaoyaosan through gut microbiota regulation. By summarizing these studies, this review provides references for the prevention and treatment of depression and the further development of traditional Chinese medicine. KEY WORDS: Depression, Gut Microbiota, Xiaoyaosan, Antidepressant Mechanism