架起中医药学与现代生物医学沟通的桥梁

Bridging up with Frontiers of the Modern Biomedical Research is of Essence for the Development of Traditional Chinese Medicine

关键词:  中医药学  实观世界  通活学  精准医学  全民基因组测序工程

Key words:  traditional chinese medicine  biomedical science  holovivology  precision medicine  genome sequencing for all

摘要:

如何推动发展中的中医药学与现代生物医学以及临床医学的深入沟通并实现互利共赢，成为我国现代医学实践和教育事业必须要认真面对的问题。现代生命科学的发生和发展经历了宏观、微观和实观三个世界。中医药学是基于宏观生物世界所建立的理论和实践体系，而现代生物医学科学在不到百年的时间里已经跨过微观世界而进入了实观世界。实观世界的科学范式是通活学（holovivology），即将生命科学带进以时空为轴心的全参数、数字化、可数字孪生的新境界。尽管传统中华医药学没有现代分子生物学的“分子-细胞”和“基因型-表型”等概念，但在过去的几十年里，现代中医药学，尤其是在中药研发方面，还是采纳了现代生物医学和药学的诸多科学方法和实验体系。如果我们运用中华传统哲学思想，指导性引进“五行”思维框架，将现代生命科学理论范畴分为“五流”（信息流、操作流、平衡流、分室流和可塑流），为中医药学理论和与现代医学理论沟通开拓了有效途径。

Abstract:

Life sciences, together with its leading field biomedical science, have been experiencing a paradigm shift, a transition from micro-biosphere to holovivo-biospere, and so have the fields of traditional Chinese medicine. The new paradigm adapts the five-elements framework from ancient philosophical syntheses, which stratifies biology and its omics-based divisions into five distinct tracks: information, operation, homeostasis, compartmentation and plasticity. With the launch of large-scale projects, such as the Human Genome Project, Precision Medicine Project, and RNAome project, biomedical research activities accelerate the transition of life sciences into the new paradigm for profound integration. Therefore, to bridge up with such frontiers is vital for traditional Chinese medicine to become a corner stone for the building of healthcare service and pharmaceutical industries in China..